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C57BL/6JCya-Drg2em1flox/Cya
Common Name:
Drg2-flox
Product ID:
S-CKO-02096
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Drg2-flox
Strain ID
CKOCMP-13495-Drg2-B6J-VA
Gene Name
Drg2
Product ID
S-CKO-02096
Gene Alias
DRG-2
Background
C57BL/6JCya
NCBI ID
13495
Modification
Conditional knockout
Chromosome
11
Phenotype
MGI:1342307
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Drg2em1flox/Cya mice (Catalog S-CKO-02096) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000018568
NCBI RefSeq
NM_021354
Target Region
Exon 4~5
Size of Effective Region
~1.3 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Drg2, or developmentally regulated GTP-binding protein 2, is a GTP-binding protein involved in multiple cellular functions. It is crucial in pathways related to cell growth, inflammation, and microtubule dynamics, which are essential for normal cell function and development. Genetic models, such as knockout (KO) mice, have been instrumental in studying Drg2's function.

DRG2 deficiency in endothelial cells promotes senescence and vascular endothelial dysfunction, as DRG2 KO mice show reduced cerebral blood flow and lung blood vessel density, along with decreased angiogenic capability of endothelial cells [1]. In macrophages, DRG2 is crucial for the initial inflammatory response against Listeria monocytogenes infection, as both whole-body and macrophage-specific DRG2 KO mice have low IL-6 levels during early infection and increased susceptibility to the infection [2]. In melanoma, DRG2 is required for the growth of primary tumors and metastases, and its inhibition suppresses VEGF-A expression [3]. In the brain, DRG2 KO mice display impaired motor behaviors with reduced striatal dopamine release [4].

In conclusion, Drg2 is a key regulator in multiple biological processes. The use of Drg2 KO mouse models has revealed its importance in vascular function, immune response, tumor growth, and neurological function. Understanding Drg2's function provides insights into the mechanisms of related diseases, potentially guiding the development of new therapeutic strategies.

References:
1. Le, Anh-Nhung, Park, Seong-Soon, Le, Minh-Xuan, Ha, Chang Man, Park, Jeong Woo. 2022. DRG2 Depletion Promotes Endothelial Cell Senescence and Vascular Endothelial Dysfunction. In International journal of molecular sciences, 23, . doi:10.3390/ijms23052877. https://pubmed.ncbi.nlm.nih.gov/35270019/
2. Lee, Unn Hwa, Park, Sang Jin, Ju, Seong A, Cho, Wha Ja, Park, Jeong Woo. 2023. DRG2 in macrophages is crucial for initial inflammatory response and protection against Listeria monocytogenes infection. In Clinical immunology (Orlando, Fla.), 257, 109819. doi:10.1016/j.clim.2023.109819. https://pubmed.ncbi.nlm.nih.gov/37918467/
3. Yoon, Nal Ae, Jung, Se Jin, Choi, Seong Hee, Cha, Hee Jeong, Park, Jeong Woo. 2019. DRG2 supports the growth of primary tumors and metastases of melanoma by enhancing VEGF-A expression. In The FEBS journal, 287, 2070-2086. doi:10.1111/febs.15125. https://pubmed.ncbi.nlm.nih.gov/31693298/
4. Lim, Hye Ryeong, Vo, Mai-Tram, Kim, Dong Jun, Park, Jeong Woo, Ha, Chang Man. 2019. DRG2 Deficient Mice Exhibit Impaired Motor Behaviors with Reduced Striatal Dopamine Release. In International journal of molecular sciences, 21, . doi:10.3390/ijms21010060. https://pubmed.ncbi.nlm.nih.gov/31861806/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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