C57BL/6JCya-Elf1em1flox/Cya
Common Name
Elf1-flox
Product ID
S-CKO-02182
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-13709-Elf1-B6J-VA
Status
When using this mouse strain in a publication, please cite “Elf1-flox Mouse (Catalog S-CKO-02182) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Elf1-flox
Strain ID
CKOCMP-13709-Elf1-B6J-VA
Gene Name
Product ID
S-CKO-02182
Gene Alias
p70, Sts1, Elf-1, mElf-1
Background
C57BL/6JCya
Gene Full Name
E74 like ETS transcription factor 1
Modification
Conditional knockout
NCBI ID
Phenotype
Chromosome
Chr 14 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000040131
NCBI Transcript ID
NM_007920
Target Region
Exon 3
Size of Effective Region
~1.0 kb
Overview of Gene Research
Elf1, also known as E74-like factor 1, is a transcription factor belonging to the Ets family. It plays diverse roles in multiple biological processes. In transcription, it has been associated with transcription-coupled repair pathways [4,8]. In the context of immunity, it is involved in macrophage development [5]. It also has implications in cell proliferation, migration, and autophagy regulation, thus being linked to various disease-related pathways [2,3,6]. Genetic models such as zebrafish are valuable for studying its functions [5].
In systemic lupus erythematosus (SLE) patients, ELF1 gene expression is significantly downregulated in CD4+ T cells compared to healthy controls. Its expression is also decreased in certain SLE subgroups, and ROC curve analysis indicates its diagnostic potential for SLE, as well as its value in assessing disease activity and renal involvement [1]. In early pregnancy loss (EPL), ELF1 is lowly expressed in placental villous tissues. Overexpression of ELF1 promotes proliferation and migration of trophoblast cells, suggesting its role in EPL [2]. In glioma, high expression of ELF1 may be related to the malignant behavior of the tumor, as silencing ELF1 inhibits glioma cell growth and migration with ATF5 involvement [3]. In lung cancer cells, ELF1 suppresses autophagy to reduce cisplatin resistance via the miR-152-3p/NCAM1/ERK axis [6]. In gastric cancer, ELF1 is overexpressed and combined with MMP9, it can serve as a predictor of malignant biological behavior and a prognostic indicator, being associated with the tumor microenvironment [7].
In conclusion, Elf1 has essential functions in transcription-coupled repair, macrophage development, and processes related to cell proliferation, migration, and autophagy. Its study through model-based research has revealed its significance in diseases like SLE, EPL, glioma, lung cancer, and gastric cancer. These findings provide insights into disease mechanisms and potential therapeutic targets.
References：
1. Zhang, Yukun, Cai, Minglong, Huang, Xiaoyi, Gao, Jinping, Sheng, Yujun. 2024. ELF1 serves as a potential biomarker for the disease activity and renal involvement in systemic lupus erythematosus. In Scientific reports, 14, 26590. doi:10.1038/s41598-024-78593-y. https://pubmed.ncbi.nlm.nih.gov/39496744/
2. Zhu, Pengfei, Dou, Chengli, Song, Zhijiao, Wu, Xueqing, Miao, Yiliang. . ELF1/PRR11/ARP2/3 promoted trophoblast cells proliferation and motility in early pregnancy. In American journal of reproductive immunology (New York, N.Y. : 1989), 90, e13758. doi:10.1111/aji.13758. https://pubmed.ncbi.nlm.nih.gov/37641376/
3. Hu, Ming, Li, Huanting, Xie, Hongwei, Ma, Junwei, Che, Shusheng. 2021. ELF1 Transcription Factor Enhances the Progression of Glioma via ATF5 promoter. In ACS chemical neuroscience, 12, 1252-1261. doi:10.1021/acschemneuro.1c00070. https://pubmed.ncbi.nlm.nih.gov/33720698/
4. Selvam, Kathiresan, Xu, Jun, Wilson, Hannah E, Wang, Dong, Wyrick, John J. 2024. Elf1 promotes transcription-coupled repair in yeast by using its C-terminal domain to bind TFIIH. In Nature communications, 15, 6223. doi:10.1038/s41467-024-50539-y. https://pubmed.ncbi.nlm.nih.gov/39043658/
5. Tan, Qianli, Wang, Jing, Hao, Yimei, Pan, Weijun, Cao, Mengye. 2025. Elf1 Deficiency Impairs Macrophage Development in Zebrafish Model Organism. In International journal of molecular sciences, 26, . doi:10.3390/ijms26062537. https://pubmed.ncbi.nlm.nih.gov/40141178/
6. Zhao, Lifeng, Wu, Xiangsheng, Zhang, Zhiwen, Yang, Bo, Li, Yepeng. 2023. ELF1 suppresses autophagy to reduce cisplatin resistance via the miR-152-3p/NCAM1/ERK axis in lung cancer cells. In Cancer science, 114, 2650-2663. doi:10.1111/cas.15770. https://pubmed.ncbi.nlm.nih.gov/36846943/
7. Zhang, Xiaoxia, Ren, Xiaoyan, Zhang, Shu, Wang, Yan. 2024. Overexpression of ELF1 combined with MMP9 is associated with prognosis and tumor microenvironment in gastric cancer. In Experimental and therapeutic medicine, 28, 441. doi:10.3892/etm.2024.12730. https://pubmed.ncbi.nlm.nih.gov/39583246/
8. Sarsam, Reta D, Xu, Jun, Lahiri, Indrajit, Wang, Dong, Leschziner, Andres E. 2024. Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair. In Proceedings of the National Academy of Sciences of the United States of America, 121, e2314245121. doi:10.1073/pnas.2314245121. https://pubmed.ncbi.nlm.nih.gov/38194460/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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