C57BL/6JCya-Erbb4em1flox/Cya
Common Name
Erbb4-flox
Product ID
S-CKO-02248
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-13869-Erbb4-B6J-VA
When using this mouse strain in a publication, please cite “Erbb4-flox Mouse (Catalog S-CKO-02248) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Erbb4-flox
Strain ID
CKOCMP-13869-Erbb4-B6J-VA
Gene Name
Product ID
S-CKO-02248
Gene Alias
Her4, c-erbB-4
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 1
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000121473
NCBI RefSeq
NM_010154
Target Region
Exon 2
Size of Effective Region
~0.7 kb
Overview of Gene Research
ErbB4, also known as HER4, is a member of the ERBB family of receptor tyrosine kinases [3]. It plays well-defined roles in normal tissue development, especially in the heart, nervous system, and mammary gland system. It is activated by ligands like neuregulin 1 (NRG1) and neuregulin 4 (NRG4), and its signaling is involved in multiple pathways that regulate cell proliferation, differentiation, apoptosis, and migration [2,4,6].
Knockout models have demonstrated embryonic lethality due to disrupted heart and brain development, highlighting its crucial role in these processes [2]. In metabolic disorders, studies show that NRG4-ErbB4 signaling is involved in preserving metabolic homeostasis. For example, peripheral NRG4 can act on hypothalamic ErbB4 to excite oxytocin neurons and reduce obesity-related metabolic disorders. Also, NRG4-ErbB4 signaling represses proinflammatory macrophage activity, potentially a target for colitis treatment [4,5,7]. In the context of cancer, ErbB4 seems to have a dual role. While it has growth-inhibiting properties and may act as a tumor suppressor, there are also conflicting data suggesting it can be involved in pro-tumorigenic mechanisms [1,3]. In psoriasis, high expression of ErbB4 in clinical samples promotes psoriasis progression by affecting Th1/Th17 cell differentiation through the IL23/IL17A signal axis [8].
In conclusion, ErbB4 is essential for normal tissue development, especially in the heart and brain. Its role in metabolic disorders and cancer has been increasingly studied. The use of knockout mouse models has been crucial in revealing its functions in these biological processes and disease conditions, providing insights into potential therapeutic targets for related diseases.
References：
1. Segers, Vincent F M, Dugaucquier, Lindsey, Feyen, Eline, Shakeri, Hadis, De Keulenaer, Gilles W. 2020. The role of ErbB4 in cancer. In Cellular oncology (Dordrecht, Netherlands), 43, 335-352. doi:10.1007/s13402-020-00499-4. https://pubmed.ncbi.nlm.nih.gov/32219702/
2. Pitcher, Jamie-Lee, Alexander, Naomi, Miranda, Panimaya Jeffreena, Johns, Terrance G. 2022. ErbB4 in the brain: Focus on high grade glioma. In Frontiers in oncology, 12, 983514. doi:10.3389/fonc.2022.983514. https://pubmed.ncbi.nlm.nih.gov/36119496/
3. Lucas, Lauren M, Dwivedi, Vipasha, Senfeld, Jared I, Shen, Jianzhong, Riese, David J. . The Yin and Yang of ERBB4: Tumor Suppressor and Oncoprotein. In Pharmacological reviews, 74, 18-47. doi:10.1124/pharmrev.121.000381. https://pubmed.ncbi.nlm.nih.gov/34987087/
4. Vulf, Maria, Bograya, Maria, Komar, Alexandra, Gazatova, Natalia, Litvinova, Larisa. . NGR4 and ERBB4 as Promising Diagnostic and Therapeutic Targets for Metabolic Disorders. In Frontiers in bioscience (Elite edition), 15, 14. doi:10.31083/j.fbe1502014. https://pubmed.ncbi.nlm.nih.gov/37369570/
5. Zhang, Yi, Zhu, Yangyang, Wang, Jinghui, Jia, Weiping, Hu, Cheng. 2023. Neuregulin4 Acts on Hypothalamic ErBb4 to Excite Oxytocin Neurons and Preserve Metabolic Homeostasis. In Advanced science (Weinheim, Baden-Wurttemberg, Germany), 10, e2204824. doi:10.1002/advs.202204824. https://pubmed.ncbi.nlm.nih.gov/37060105/
6. Wan, Chaofan, Xia, Yucen, Yan, Jinglan, Yin, Dong-Min, Chen, Yongjun. 2024. nNOS in Erbb4-positive neurons regulates GABAergic transmission in mouse hippocampus. In Cell death & disease, 15, 167. doi:10.1038/s41419-024-06557-1. https://pubmed.ncbi.nlm.nih.gov/38396027/
7. Schumacher, Michael A, Dennis, Isabella C, Liu, Cambrian Y, Polk, D Brent, Frey, Mark R. 2021. NRG4-ErbB4 signaling represses proinflammatory macrophage activity. In American journal of physiology. Gastrointestinal and liver physiology, 320, G990-G1001. doi:10.1152/ajpgi.00296.2020. https://pubmed.ncbi.nlm.nih.gov/33826403/
8. Tang, Rongrong, Cui, Haiyan, Dou, Rongrong, Guo, Ting, Luo, Dan. 2023. ErbB4 affects Th1/Th17 cell differentiation and promotes psoriasis progression. In Cellular and molecular biology (Noisy-le-Grand, France), 69, 1-5. doi:10.14715/cmb/2023.69.12.1. https://pubmed.ncbi.nlm.nih.gov/38063127/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.