F2rl1, also known as F2R like trypsin receptor 1 and encoding protease-activated receptor-2 (PAR2), is a G-protein coupled receptor. PAR2 is involved in various physiological and pathological processes. It is associated with inflammatory responses and may be involved in multiple signaling pathways, such as the Hippo signaling pathway [1]. It has significance in numerous biological processes and disease conditions.

In diabetic kidney disease (DKD), knockdown of F2rl1 significantly reduced the inflammatory response in palmitate-stimulated HK-2 cells, suggesting that F2rl1 might exacerbate lipotoxicity-induced DKD through the modulation of the Hippo signaling pathway, indicating its potential as a therapeutic target for DKD [1]. In cervical cancer, high F2RL1 expression is linked to reduced overall survival, progression-free interval, and progression-free survival. Also, its expression levels impact different N stages, pathological tissue types, treatment statuses, and racial groups, and there is an inverse proportion between its expression and the infiltration of most immune cells, suggesting a role in immune evasion [2].

In conclusion, F2rl1 plays important roles in inflammatory responses and disease progression, such as in DKD and cervical cancer. The study of F2rl1 through knockdown and other functional studies helps to understand its functions in disease-related biological processes, providing potential directions for disease treatment.