C57BL/6JCya-Fgfr1em1flox/Cya
Common Name:
Fgfr1-flox
Product ID:
S-CKO-02414
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Fgfr1-flox
Strain ID
CKOCMP-14182-Fgfr1-B6J-VA
Gene Name
Product ID
S-CKO-02414
Gene Alias
Eask; FGFR-I; FLG; Fgfr-1; Flt-2; Fr1; Hspy; MFR; bFGF-R-1; c-fgr
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
8
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Fgfr1em1flox/Cya mice (Catalog S-CKO-02414) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000084027
NCBI RefSeq
NM_010206
Target Region
Exon 4~5
Size of Effective Region
~1.9 kb
Detailed Document
Overview of Gene Research
Fgfr1, fibroblast growth factor receptor 1, is a transmembrane cytokine receptor. It is crucial for early human embryo development, participating in gastrulation, organ specification, and tissue patterning. It is involved in multiple pathways, such as the PLCγ-NF-κB inflammatory signalling pathway [1].
In a mouse model, deletion of myeloid-expressed Fgfr1 in Apoe-/-mice reduced atherosclerotic lesions and lipid accumulations, indicating that Fgfr1 in macrophages promotes atherosclerosis through the PLCγ-mediated activation of the NF-κB inflammatory signalling pathway [1]. In prostate cancer cells, deletion of Fgfr1 in DU145 cells decreased the labile iron pool, suggesting its role in iron homeostasis [2].
In conclusion, Fgfr1 is essential for embryo development and is involved in multiple disease-related processes. The gene knockout mouse models have revealed its role in atherosclerosis and prostate cancer, providing insights into potential therapeutic targets for these diseases.
References:
1. Wang, Lintao, Luo, Wu, Zhang, Suya, Xu, Biao, Liang, Guang. . Macrophage-derived FGFR1 drives atherosclerosis through PLCγ-mediated activation of NF-κB inflammatory signalling pathway. In Cardiovascular research, 120, 1385-1399. doi:10.1093/cvr/cvae131. https://pubmed.ncbi.nlm.nih.gov/38842387/
2. Lin, Hui, Lin, Shuaijun, Shi, Liuhong, Pan, Xuebo, Wang, Cong. 2024. FGFR1 governs iron homeostasis via regulating intracellular protein degradation pathways of IRP2 in prostate cancer cells. In Communications biology, 7, 1011. doi:10.1038/s42003-024-06704-6. https://pubmed.ncbi.nlm.nih.gov/39154074/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen