C57BL/6JCya-Fgfr2em1flox/Cya
Common Name:
Fgfr2-flox
Product ID:
S-CKO-02415
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Fgfr2-flox
Strain ID
CKOCMP-14183-Fgfr2-B6J-VA
Gene Name
Product ID
S-CKO-02415
Gene Alias
Bek; Fgfr-2; Fgfr-7; Fgfr2b; Fgfr7; KGFR; KGFRTr; svs
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
7
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Fgfr2em1flox/Cya mice (Catalog S-CKO-02415) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000122054
NCBI RefSeq
NM_010207
Target Region
Exon 5
Size of Effective Region
~1.2 kb
Detailed Document
Overview of Gene Research
Fgfr2, short for Fibroblast Growth Factor Receptor 2, is a crucial receptor tyrosine kinase. It is involved in various biological processes through activation of fibroblast growth factor signaling pathways, which are essential for cell growth, differentiation, development, and tissue repair [3].
Somatic hotspot mutations, structural amplifications, and fusions of Fgfr2 occur in multiple cancers. Transposon-based screening and tumour modelling in mice identified that truncation of exon 18 of Fgfr2 is a potent driver mutation. Genomic alterations generating stable FGFR2ΔE18 variants are actionable therapeutic targets, confirmed in preclinical mouse and human tumour models, and a clinical trial [3]. In cholangiocarcinoma, FGFR2 fusions, occurring in 10-15% of intrahepatic cholangiocarcinoma patients, have become a promising target for precision oncology. FGFR inhibitors like futibatinib, pemigatinib, and others have shown clinical benefit in patients with FGFR2-altered cholangiocarcinoma, but issues like acquired resistance need further study [1,2,4].
In conclusion, Fgfr2 plays a vital role in cell growth, differentiation, and development through its signaling pathways. The study of Fgfr2 in mouse models has revealed its significance in cancer, especially in cholangiocarcinoma, where FGFR2-targeted therapies are being developed. Understanding Fgfr2's functions and associated mutations provides potential therapeutic strategies for treating related cancers.
References:
1. Vogel, Arndt, Segatto, Oreste, Stenzinger, Albrecht, Saborowski, Anna. 2022. FGFR2 Inhibition in Cholangiocarcinoma. In Annual review of medicine, 74, 293-306. doi:10.1146/annurev-med-042921-024707. https://pubmed.ncbi.nlm.nih.gov/36170665/
2. Goyal, Lipika, Meric-Bernstam, Funda, Hollebecque, Antoine, Benhadji, Karim A, Bridgewater, John A. . Futibatinib for FGFR2-Rearranged Intrahepatic Cholangiocarcinoma. In The New England journal of medicine, 388, 228-239. doi:10.1056/NEJMoa2206834. https://pubmed.ncbi.nlm.nih.gov/36652354/
3. Zingg, Daniel, Bhin, Jinhyuk, Yemelyanenko, Julia, Wessels, Lodewyk F A, Jonkers, Jos. 2022. Truncated FGFR2 is a clinically actionable oncogene in multiple cancers. In Nature, 608, 609-617. doi:10.1038/s41586-022-05066-5. https://pubmed.ncbi.nlm.nih.gov/35948633/
4. Storandt, Michael H, Jin, Zhaohui, Mahipal, Amit. 2022. Pemigatinib in cholangiocarcinoma with a FGFR2 rearrangement or fusion. In Expert review of anticancer therapy, 22, 1265-1274. doi:10.1080/14737140.2022.2150168. https://pubmed.ncbi.nlm.nih.gov/36408971/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen