C57BL/6NCya-Fntaem1flox/Cya
Common Name
Fnta-flox
Product ID
S-CKO-02472
Backgroud
C57BL/6NCya
Strain ID
CKOCMP-14272-Fnta-B6N-VA
When using this mouse strain in a publication, please cite “Fnta-flox Mouse (Catalog S-CKO-02472) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Fnta-flox
Strain ID
CKOCMP-14272-Fnta-B6N-VA
Gene Name
Product ID
S-CKO-02472
Gene Alias
FTA
Background
C57BL/6NCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 8
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000016138
NCBI RefSeq
NM_008033
Target Region
Exon 3
Size of Effective Region
~0.6 kb
Overview of Gene Research
FnTA, also known as the alpha subunit of human CAAX farnesyltransferase, is a key component of the enzyme that attaches a farnesyl group to specific cellular proteins ending with a "CAAXbox", such as p21ras proteins, nuclear lamins, and some retinal proteins. This post-translational modification is involved in multiple cellular processes, influencing protein function and localization within the cell [2].
In bladder cancer, circ-FNTA, a circular RNA related to the FNTA gene, has been studied. High levels of circ-FNTA in bladder cancer tissues are associated with worse prognosis. Silencing circ-FNTA attenuates the proliferative and invasive abilities of bladder cancer cells. circ-FNTA accelerates these processes through targeting the miRNA-451a/S1PR3 axis [1]. Additionally, androgen receptor-regulated circFNTA activates KRAS signaling to promote bladder cancer invasion. AR represses the RNA editing gene ADAR2 to increase circFNTA levels, which then affects miR-370-3p and FNTA expression, ultimately altering bladder cancer cell invasion and chemo-sensitivity [3].
In summary, FnTA and its related circular RNA circ-FNTA play important roles in bladder cancer progression. Understanding these relationships helps in revealing the molecular mechanisms of bladder cancer and may provide potential therapeutic targets for the disease.
References：
1. Tian, Jianhai, Fan, Jiqiang, Xu, Jianping, Guo, Huaiyuan, Zhou, Lulian. 2019. circ-FNTA accelerates proliferation and invasion of bladder cancer. In Oncology letters, 19, 1017-1023. doi:10.3892/ol.2019.11150. https://pubmed.ncbi.nlm.nih.gov/31897215/
2. Andres, D A, Milatovich, A, Ozçelik, T, Goldstein, J L, Francke, U. . cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences. In Genomics, 18, 105-12. doi:. https://pubmed.ncbi.nlm.nih.gov/8276393/
3. Chen, Jinbo, Sun, Yin, Ou, Zhenyu, Zu, Xiongbing, Chang, Chawnshang. 2020. Androgen receptor-regulated circFNTA activates KRAS signaling to promote bladder cancer invasion. In EMBO reports, 21, e48467. doi:10.15252/embr.201948467. https://pubmed.ncbi.nlm.nih.gov/32052578/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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