C57BL/6NCya-Fntaem1flox/Cya
Common Name:
Fnta-flox
Product ID:
S-CKO-02472
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Fnta-flox
Strain ID
CKOCMP-14272-Fnta-B6N-VA
Gene Name
Product ID
S-CKO-02472
Gene Alias
FTA
Background
C57BL/6NCya
NCBI ID
Modification
Conditional knockout
Chromosome
8
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Fntaem1flox/Cya mice (Catalog S-CKO-02472) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000016138
NCBI RefSeq
NM_008033
Target Region
Exon 3
Size of Effective Region
~0.6 kb
Detailed Document
Overview of Gene Research
FnTA, also known as the alpha subunit of human CAAX farnesyltransferase, is a key component of the enzyme that attaches a farnesyl group to specific cellular proteins ending with a "CAAXbox", such as p21ras proteins, nuclear lamins, and some retinal proteins. This post-translational modification is involved in multiple cellular processes, influencing protein function and localization within the cell [2].
In bladder cancer, circ-FNTA, a circular RNA related to the FNTA gene, has been studied. High levels of circ-FNTA in bladder cancer tissues are associated with worse prognosis. Silencing circ-FNTA attenuates the proliferative and invasive abilities of bladder cancer cells. circ-FNTA accelerates these processes through targeting the miRNA-451a/S1PR3 axis [1]. Additionally, androgen receptor-regulated circFNTA activates KRAS signaling to promote bladder cancer invasion. AR represses the RNA editing gene ADAR2 to increase circFNTA levels, which then affects miR-370-3p and FNTA expression, ultimately altering bladder cancer cell invasion and chemo-sensitivity [3].
In summary, FnTA and its related circular RNA circ-FNTA play important roles in bladder cancer progression. Understanding these relationships helps in revealing the molecular mechanisms of bladder cancer and may provide potential therapeutic targets for the disease.
References:
1. Tian, Jianhai, Fan, Jiqiang, Xu, Jianping, Guo, Huaiyuan, Zhou, Lulian. 2019. circ-FNTA accelerates proliferation and invasion of bladder cancer. In Oncology letters, 19, 1017-1023. doi:10.3892/ol.2019.11150. https://pubmed.ncbi.nlm.nih.gov/31897215/
2. Andres, D A, Milatovich, A, Ozçelik, T, Goldstein, J L, Francke, U. . cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences. In Genomics, 18, 105-12. doi:. https://pubmed.ncbi.nlm.nih.gov/8276393/
3. Chen, Jinbo, Sun, Yin, Ou, Zhenyu, Zu, Xiongbing, Chang, Chawnshang. 2020. Androgen receptor-regulated circFNTA activates KRAS signaling to promote bladder cancer invasion. In EMBO reports, 21, e48467. doi:10.15252/embr.201948467. https://pubmed.ncbi.nlm.nih.gov/32052578/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen