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C57BL/6JCya-Fzd6em1flox/Cya
Common Name:
Fzd6-flox
Product ID:
S-CKO-02512
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Fzd6-flox
Strain ID
CKOCMP-14368-Fzd6-B6J-VA
Gene Name
Fzd6
Product ID
S-CKO-02512
Gene Alias
Fz6; rst
Background
C57BL/6JCya
NCBI ID
14368
Modification
Conditional knockout
Chromosome
15
Phenotype
MGI:108474
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Fzd6em1flox/Cya mice (Catalog S-CKO-02512) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000179165
NCBI RefSeq
NM_001162494
Target Region
Exon 4
Size of Effective Region
~2.4 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Fzd6, a member of the Frizzled family of G protein-coupled receptors, is a key mediator in Wnt signaling pathways. Wnt ligands bind to Fzd6, along with co-receptors like Lrp5/6, to initiate either canonical or non-canonical Wnt signaling, which play fundamental roles in cell differentiation, tissue polarity during development, and stem cell specification and activity [1,2,3].

In lung alveoli, Fzd6 is expressed in epithelial cells and, unexpectedly, activation of non-canonical Fzd6 can stimulate alveolar epithelial stem cell activity and promote an alveolar fate in airway-derived progenitors, offering a potential lung injury regeneration strategy [1].

In melanoma, knockout of Fzd6 significantly reduces cell invasion and lung metastasis, revealing its role in melanoma progression via regulating canonical Wnt signaling and epithelial-mesenchymal transition [2].

In osteoporotic mice, Fzd6 silencing down-regulates the osteogenic ability of adipose-derived stem cells both in vitro and in vivo, indicating its importance in regulating osteogenic differentiation [4].

In conclusion, Fzd6 is crucial for multiple biological processes through its involvement in Wnt signaling. Studies using gene knockout mouse models have revealed its roles in lung injury regeneration, melanoma progression, and osteogenic differentiation, providing insights into potential therapeutic strategies for related diseases.

References:
1. Nabhan, Ahmad N, Webster, Joshua D, Adams, Jarret J, Arron, Joseph R, Dixit, Vishva M. 2023. Targeted alveolar regeneration with Frizzled-specific agonists. In Cell, 186, 2995-3012.e15. doi:10.1016/j.cell.2023.05.022. https://pubmed.ncbi.nlm.nih.gov/37321220/
2. Dong, Bo, Simonson, Laura, Vold, Samantha, Ahmad, Nihal, Chang, Hao. 2022. FZD6 Promotes Melanoma Cell Invasion but Not Proliferation by Regulating Canonical Wnt Signaling and Epithelial‒Mesenchymal Transition. In The Journal of investigative dermatology, 143, 621-629.e6. doi:10.1016/j.jid.2022.09.658. https://pubmed.ncbi.nlm.nih.gov/36368445/
3. Corda, G, Sala, A. 2017. Non-canonical WNT/PCP signalling in cancer: Fzd6 takes centre stage. In Oncogenesis, 6, e364. doi:10.1038/oncsis.2017.69. https://pubmed.ncbi.nlm.nih.gov/28737757/
4. Wu, Tianli, Yao, Zhihao, Tao, Gang, Yang, Xiaojuan, Xiao, Jingang. 2021. Role of Fzd6 in Regulating the Osteogenic Differentiation of Adipose-derived Stem Cells in Osteoporotic Mice. In Stem cell reviews and reports, 17, 1889-1904. doi:10.1007/s12015-021-10182-2. https://pubmed.ncbi.nlm.nih.gov/34041696/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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