Gabrb2, which encodes the β2 subunit of the GABAA receptor, is a key gene in the central nervous system [1]. GABAA receptors are pentameric and part of the Cys-loop superfamily, playing crucial roles in synaptogenesis, neurogenesis, and the regulation of neuronal plasticity and learning [1]. The β2 subunit combines with α and γ subunits to form a major GABAA receptor subtype, accounting for 43% of all such receptors in the mammalian brain [1].

Gabrb2 knockout mice have been instrumental in understanding its functions. These mice exhibit schizophrenia-like behavior, neuroinflammation, and double-directed PMDD-like symptoms [1,3,4]. The phenotypes in knockout mice also include PPI deficit, locomotor hyperactivity, sociability impairments, memory deficits, and changes in depression and anxiety levels [4]. Some of these phenotypes can be ameliorated by drugs like risperidone [1,4]. Additionally, functional analysis of variants in Gabrb2 in a Xenopus laevis oocyte model system has provided insights into its role in epilepsy [2].

In conclusion, Gabrb2 is essential for normal central nervous system function. The study of Gabrb2 knockout mouse models has revealed its significance in various neuropsychiatric disorders, including schizophrenia, PMDD, and epilepsy. Understanding Gabrb2's functions may lead to the development of new therapeutic approaches for these disorders.