The provided references do not contain information directly related to the gene Gem. They mainly focus on chemical syntheses such as gem-difluorinations [1,4,6,7,10], gem-diborylalkanes [2,8], and other chemical compounds and concepts like the Guideline Elements Model (GEM) [3], and a collaboration software GEM-NET [5], as well as properties and applications of various gem-substituted organic compounds [9]. Without relevant information about the gene Gem, it's not possible to accurately introduce its function, associated pathways, and importance as per the requirements.

However, generally speaking, if Gem were a gene, gene knockout (KO) or conditional knockout (CKO) mouse models could be used to study its function. In KO mouse models, the complete absence of the Gem gene product could reveal its essential roles in biological processes. For example, if a KO mouse shows abnormal development, it might indicate that Gem is involved in developmental pathways. In CKO mouse models, tissue-specific or time-specific inactivation of Gem can help pinpoint its functions in particular tissues or at specific stages of development or disease progression. These models are crucial research tools for in vivo studies of gene function and understanding how Gem might be involved in relevant diseases.