C57BL/6JCya-Ggps1em1flox/Cya
Common Name:
Ggps1-flox
Product ID:
S-CKO-02620
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Ggps1-flox
Strain ID
CKOCMP-14593-Ggps1-B6J-VA
Gene Name
Product ID
S-CKO-02620
Gene Alias
1810026C22Rik; 9530089B04Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
13
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ggps1em1flox/Cya mice (Catalog S-CKO-02620) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000170957
NCBI RefSeq
NM_010282
Target Region
Exon 3
Size of Effective Region
~1.0 kb
Detailed Document
Overview of Gene Research
Ggps1, or geranylgeranyl diphosphate synthase 1, is a member of the prenyltransferase family. It functions in the mevalonate/isoprenoid pathway, catalyzing the synthesis of geranylgeranyl pyrophosphate, a lipid precursor for geranylgeranylated proteins like small guanosine triphosphatases [2]. This process is crucial as abnormal Ggps1 expression can disrupt protein farnesylation and geranylgeranylation balance, affecting various cellular physiological and pathological processes [3].
In a myometrial cell-specific Ggps1-deleted mouse model, Ggps1 deficiency in the uterus led to impaired uterine contractions, disrupted embryonic placing, and dystocia. Mechanistically, Ggps1 is required for uterine contractions by regulating RhoA prenylation to activate the RhoA/Rock2/p-MLC pathway [1]. Also, a Ggps1 Y259C knock-in mouse resulted in prenatal lethality, indicating the importance of Ggps1 in normal development [2].
In conclusion, Ggps1 is essential for processes such as uterine contraction during parturition and normal development. Its deficiency can lead to severe consequences like dystocia and prenatal lethality. Research on Ggps1 using mouse models has provided insights into its role in these biological processes and diseases related to muscular dystrophy, hearing loss, and ovarian insufficiency [1,2].
References:
1. Sang, Yong-Juan, Wang, Qiang, Zheng, Feng, Sun, Hai-Xiang, Li, Chao-Jun. . Ggps1 deficiency in the uterus results in dystocia by disrupting uterine contraction. In Journal of molecular cell biology, 13, 116-127. doi:10.1093/jmcb/mjaa066. https://pubmed.ncbi.nlm.nih.gov/33340314/
2. Foley, A Reghan, Zou, Yaqun, Dunford, James E, Stojkovic, Tanya, Bönnemann, Carsten G. 2020. GGPS1 Mutations Cause Muscular Dystrophy/Hearing Loss/Ovarian Insufficiency Syndrome. In Annals of neurology, 88, 332-347. doi:10.1002/ana.25772. https://pubmed.ncbi.nlm.nih.gov/32403198/
3. Huang, Ke, Han, Liang, Xu, Huimei, Wang, Huihui, Xu, Zhaoqing. 2023. The prognostic role and metabolic function of GGPS1 in oral squamous cell carcinoma. In Frontiers in molecular biosciences, 10, 1109403. doi:10.3389/fmolb.2023.1109403. https://pubmed.ncbi.nlm.nih.gov/37033446/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen