C57BL/6JCya-Gngt1em1flox/Cya
Common Name:
Gngt1-flox
Product ID:
S-CKO-02689
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Gngt1-flox
Strain ID
CKOCMP-14699-Gngt1-B6J-VA
Gene Name
Product ID
S-CKO-02689
Gene Alias
G(y)1; Gng1; Hg3g1
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
6
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Gngt1em1flox/Cya mice (Catalog S-CKO-02689) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000031673
NCBI RefSeq
NM_010314
Target Region
Exon 3
Size of Effective Region
~1.5 kb
Detailed Document
Overview of Gene Research
Gngt1, encoding the rod photoreceptor transducin gamma-subunit, is a key gene in the phototransduction cascade. As part of heterotrimeric G-protein transducin in retinal rod photoreceptor cells, it plays a crucial role in signal transduction and amplification in vision [5,6,7].
In lung adenocarcinoma (LUAD), Gngt1 is overexpressed and associated with poor prognosis. It promotes tumor metastasis by enhancing tumor stemness, remodeling the tumor microenvironment, and modulating the fibrinogen beta chain-neutrophil extracellular trap signaling axis [2]. In non-small-cell lung cancer (NSCLC), Gngt1 is identified as a hub gene, and its high expression is related to worse overall survival, suggesting its potential as a diagnostic and prognostic biomarker [3]. In the context of atrial fibrillation-related stroke, Gngt1 may be associated with stroke as a hub-gene [1]. In the study of the pineal gland's evolution, specific genes including Gngt1 were consistently present in mammalian pinealocytes, indicating its role in the functional transformation of the pineal gland from a photoreceptive to a neuroendocrine organ [4].
In conclusion, Gngt1 is essential for phototransduction in the retina. Its dysregulation is implicated in various diseases such as LUAD, NSCLC, and potentially atrial fibrillation-related stroke. Research on Gngt1, especially through in vivo models, provides insights into disease mechanisms and potential biomarker and therapeutic target identification.
References:
1. Zou, Rongjun, Zhang, Dingwen, Lv, Lei, Yang, Songran, Hua, Ping. 2019. Bioinformatic gene analysis for potential biomarkers and therapeutic targets of atrial fibrillation-related stroke. In Journal of translational medicine, 17, 45. doi:10.1186/s12967-019-1790-x. https://pubmed.ncbi.nlm.nih.gov/30760287/
2. Fan, Lin-Lin, Wang, Xiao-Wei, Zhang, Xiu-Mei, Yu, Hong, Jiang, Geng-Xi. 2025. GNGT1 remodels the tumor microenvironment and promotes immune escape through enhancing tumor stemness and modulating the fibrinogen beta chain-neutrophil extracellular trap signaling axis in lung adenocarcinoma. In Translational lung cancer research, 14, 239-259. doi:10.21037/tlcr-2024-1200. https://pubmed.ncbi.nlm.nih.gov/39958208/
3. Zhang, Jia-Jia, Hong, Jiang, Ma, Yu-Shui, Fu, Da, Yu, Fei. 2021. Identified GNGT1 and NMU as Combined Diagnosis Biomarker of Non-Small-Cell Lung Cancer Utilizing Bioinformatics and Logistic Regression. In Disease markers, 2021, 6696198. doi:10.1155/2021/6696198. https://pubmed.ncbi.nlm.nih.gov/33505535/
4. Zheng, Jihong, Song, Wenqi, Zhou, Yihang, Wang, Meng, Zhang, Chao. 2023. Cross-species single-cell landscape of vertebrate pineal gland. In Journal of pineal research, 76, e12927. doi:10.1111/jpi.12927. https://pubmed.ncbi.nlm.nih.gov/38018267/
5. Scherer, S W, Feinstein, D S, Oliveira, L, Tsui, L C, Pittler, S J. . Gene structure and chromosome localization to 7q21.3 of the human rod photoreceptor transducin gamma-subunit gene (GNGT1). In Genomics, 35, 241-3. doi:. https://pubmed.ncbi.nlm.nih.gov/8661128/
6. Kolesnikov, Alexander V, Lobysheva, Elena, Gnana-Prakasam, Jaya P, Kefalov, Vladimir J, Kisselev, Oleg G. 2022. Regulation of rod photoreceptor function by farnesylated G-protein γ-subunits. In PloS one, 17, e0272506. doi:10.1371/journal.pone.0272506. https://pubmed.ncbi.nlm.nih.gov/35939447/
7. Lagman, David, Sundström, Görel, Ocampo Daza, Daniel, Abalo, Xesús M, Larhammar, Dan. 2012. Expansion of transducin subunit gene families in early vertebrate tetraploidizations. In Genomics, 100, 203-11. doi:10.1016/j.ygeno.2012.07.005. https://pubmed.ncbi.nlm.nih.gov/22814267/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen