C57BL/6JCya-Gngt1em1flox/Cya
Common Name
Gngt1-flox
Product ID
S-CKO-02689
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-14699-Gngt1-B6J-VA
When using this mouse strain in a publication, please cite “Gngt1-flox Mouse (Catalog S-CKO-02689) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Gngt1-flox
Strain ID
CKOCMP-14699-Gngt1-B6J-VA
Gene Name
Product ID
S-CKO-02689
Gene Alias
Gng1, G(y)1, Hg3g1
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 6
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000031673
NCBI RefSeq
NM_010314
Target Region
Exon 3
Size of Effective Region
~1.5 kb
Overview of Gene Research
Gngt1, encoding the rod photoreceptor transducin gamma-subunit, is a key gene in the phototransduction cascade. As part of heterotrimeric G-protein transducin in retinal rod photoreceptor cells, it plays a crucial role in signal transduction and amplification in vision [5,6,7].
In lung adenocarcinoma (LUAD), Gngt1 is overexpressed and associated with poor prognosis. It promotes tumor metastasis by enhancing tumor stemness, remodeling the tumor microenvironment, and modulating the fibrinogen beta chain-neutrophil extracellular trap signaling axis [2]. In non-small-cell lung cancer (NSCLC), Gngt1 is identified as a hub gene, and its high expression is related to worse overall survival, suggesting its potential as a diagnostic and prognostic biomarker [3]. In the context of atrial fibrillation-related stroke, Gngt1 may be associated with stroke as a hub-gene [1]. In the study of the pineal gland's evolution, specific genes including Gngt1 were consistently present in mammalian pinealocytes, indicating its role in the functional transformation of the pineal gland from a photoreceptive to a neuroendocrine organ [4].
In conclusion, Gngt1 is essential for phototransduction in the retina. Its dysregulation is implicated in various diseases such as LUAD, NSCLC, and potentially atrial fibrillation-related stroke. Research on Gngt1, especially through in vivo models, provides insights into disease mechanisms and potential biomarker and therapeutic target identification.
References：
1. Zou, Rongjun, Zhang, Dingwen, Lv, Lei, Yang, Songran, Hua, Ping. 2019. Bioinformatic gene analysis for potential biomarkers and therapeutic targets of atrial fibrillation-related stroke. In Journal of translational medicine, 17, 45. doi:10.1186/s12967-019-1790-x. https://pubmed.ncbi.nlm.nih.gov/30760287/
2. Fan, Lin-Lin, Wang, Xiao-Wei, Zhang, Xiu-Mei, Yu, Hong, Jiang, Geng-Xi. 2025. GNGT1 remodels the tumor microenvironment and promotes immune escape through enhancing tumor stemness and modulating the fibrinogen beta chain-neutrophil extracellular trap signaling axis in lung adenocarcinoma. In Translational lung cancer research, 14, 239-259. doi:10.21037/tlcr-2024-1200. https://pubmed.ncbi.nlm.nih.gov/39958208/
3. Zhang, Jia-Jia, Hong, Jiang, Ma, Yu-Shui, Fu, Da, Yu, Fei. 2021. Identified GNGT1 and NMU as Combined Diagnosis Biomarker of Non-Small-Cell Lung Cancer Utilizing Bioinformatics and Logistic Regression. In Disease markers, 2021, 6696198. doi:10.1155/2021/6696198. https://pubmed.ncbi.nlm.nih.gov/33505535/
4. Zheng, Jihong, Song, Wenqi, Zhou, Yihang, Wang, Meng, Zhang, Chao. 2023. Cross-species single-cell landscape of vertebrate pineal gland. In Journal of pineal research, 76, e12927. doi:10.1111/jpi.12927. https://pubmed.ncbi.nlm.nih.gov/38018267/
5. Scherer, S W, Feinstein, D S, Oliveira, L, Tsui, L C, Pittler, S J. . Gene structure and chromosome localization to 7q21.3 of the human rod photoreceptor transducin gamma-subunit gene (GNGT1). In Genomics, 35, 241-3. doi:. https://pubmed.ncbi.nlm.nih.gov/8661128/
6. Kolesnikov, Alexander V, Lobysheva, Elena, Gnana-Prakasam, Jaya P, Kefalov, Vladimir J, Kisselev, Oleg G. 2022. Regulation of rod photoreceptor function by farnesylated G-protein γ-subunits. In PloS one, 17, e0272506. doi:10.1371/journal.pone.0272506. https://pubmed.ncbi.nlm.nih.gov/35939447/
7. Lagman, David, Sundström, Görel, Ocampo Daza, Daniel, Abalo, Xesús M, Larhammar, Dan. 2012. Expansion of transducin subunit gene families in early vertebrate tetraploidizations. In Genomics, 100, 203-11. doi:10.1016/j.ygeno.2012.07.005. https://pubmed.ncbi.nlm.nih.gov/22814267/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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