C57BL/6JCya-Gstt1em1flox/Cya
Common Name:
Gstt1-flox
Product ID:
S-CKO-02784
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Gstt1-flox
Strain ID
CKOCMP-14871-Gstt1-B6J-VA
Gene Name
Product ID
S-CKO-02784
Gene Alias
Gstt1-1
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
10
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Gstt1em1flox/Cya mice (Catalog S-CKO-02784) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000001713
NCBI RefSeq
NM_008185
Target Region
Exon 3
Size of Effective Region
~1.6 kb
Detailed Document
Overview of Gene Research
Gstt1, glutathione S-transferase theta 1, encodes an enzyme responsible for the detoxification of substances potentially harmful to the human body, such as air pollution, drugs, pesticides, and tobacco [2]. The enzyme is part of the glutathione S-transferases (GST) group that protects cells from oxidative stress [1].
Some studies suggest associations between Gstt1 polymorphisms and various diseases. A meta-analysis indicated that Gstt1 homozygous deletion may increase susceptibility to pancreatic cancer [3]. In prostate cancer, the Gstt1 null genotype was associated with risk in Caucasians [4]. Gstt1 null, along with Gstm1 null, was associated with increased bladder cancer risk in Caucasians [6]. Also, in coronary heart disease, the Gstt1 null genotype was associated with increased risk, and there was a positive interaction with smoking status [7]. In lung cancer, the Gstt1 null genotype was associated with increased risk in Asians, especially in Chinese populations [8]. In CBA/CaJ mice, simultaneous deletion of Gstm1 and Gstt1 led to more profound hearing loss under cisplatin treatment, suggesting Gstt1 protects auditory hair cells from cisplatin-induced ototoxicity [5].
In conclusion, Gstt1 plays a crucial role in detoxification and protection against oxidative stress. Studies using genetic models, such as gene deletions in mice, have revealed its significance in various disease conditions including cancer, heart disease, and ototoxicity. Understanding Gstt1's function through these models provides insights into disease mechanisms and potential preventive or treatment strategies.
References:
1. Li, Lin, Wang, Ao, Ke, Yi. . GSTM1 and GSTT1 polymorphisms and risk of preeclampsia: a system review and meta-analysis. In The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 36, 2237623. doi:10.1080/14767058.2023.2237623. https://pubmed.ncbi.nlm.nih.gov/37469043/
2. Nakanishi, Giovana, Bertagnolli, Laísa S, Pita-Oliveira, Murilo, Cirino, Heithor S, Rodrigues-Soares, Fernanda. 2022. GSTM1 and GSTT1 polymorphisms in healthy volunteers - a worldwide systematic review. In Drug metabolism reviews, 54, 37-45. doi:10.1080/03602532.2022.2036996. https://pubmed.ncbi.nlm.nih.gov/35103568/
3. Cui, Jun-Peng, Lin, Mei-Yi, Liu, Zheng-Hao, Liu, Bao-Lin. . Association between GSTT1 Homozygous Deletion and Risk of Pancreatic Cancer: A Meta Analysis. In Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih, 34, 205-210. doi:10.24920/003490. https://pubmed.ncbi.nlm.nih.gov/31648673/
4. Zhou, Tian-Biao, Drummen, Gregor P C, Jiang, Zong-Pei, Qin, Yuan-Han. 2014. GSTT1 polymorphism and the risk of developing prostate cancer. In American journal of epidemiology, 180, 1-10. doi:10.1093/aje/kwu112. https://pubmed.ncbi.nlm.nih.gov/24907267/
5. Li, Peipei, Liu, Ziyi, Wang, Jinpeng, Gao, Jiangang, Fu, Xiaolong. . Gstm1/Gstt1 is essential for reducing cisplatin ototoxicity in CBA/CaJ mice. In FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 36, e22373. doi:10.1096/fj.202200324R. https://pubmed.ncbi.nlm.nih.gov/35621716/
6. Yu, Cui, Hequn, Chen, Longfei, Liu, Chao, Li, Xiongbing, Zu. . GSTM1 and GSTT1 polymorphisms are associated with increased bladder cancer risk: Evidence from updated meta-analysis. In Oncotarget, 8, 3246-3258. doi:10.18632/oncotarget.13702. https://pubmed.ncbi.nlm.nih.gov/27911277/
7. Song, Yadong, Shan, Zhilei, Luo, Cheng, Jiang, Xiaoming, Liu, Liegang. 2016. Glutathione S-Transferase T1 (GSTT1) Null Polymorphism, Smoking, and Their Interaction in Coronary Heart Disease: A Comprehensive Meta-Analysis. In Heart, lung & circulation, 26, 362-370. doi:10.1016/j.hlc.2016.07.005. https://pubmed.ncbi.nlm.nih.gov/27686690/
8. Zhang, Wen-Ping, Yang, Chen, Xu, Ling-Jun, Song, Liang, He, Xiao-Feng. . Individual and combined effects of GSTM1, GSTT1, and GSTP1 polymorphisms on lung cancer risk: A meta-analysis and re-analysis of systematic meta-analyses. In Medicine, 100, e26104. doi:10.1097/MD.0000000000026104. https://pubmed.ncbi.nlm.nih.gov/34190143/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen