C57BL/6JCya-Insrem1flox/Cya
Common Name:
Insr-flox
Product ID:
S-CKO-03135
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Insr-flox
Strain ID
CKOCMP-16337-Insr-B6J-VA
Gene Name
Product ID
S-CKO-03135
Gene Alias
4932439J01Rik; CD220; D630014A15Rik; IR; IR-A; IR-B
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
8
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Insrem1flox/Cya mice (Catalog S-CKO-03135) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000091291
NCBI RefSeq
NM_010568
Target Region
Exon 4
Size of Effective Region
~1.1 kb
Detailed Document
Overview of Gene Research
Insr, the insulin receptor gene, encodes an evolutionarily conserved signaling protein. It is crucial in the insulin signaling pathway, which is involved in metabolic regulation, growth control, and neuronal function. Dysregulation of this pathway is linked to diabetes, cancer, and neurodegenerative diseases [1].
In a conditional cortex-specific knockout mouse model lacking both Igf1r and Insr, normal development of the embryonic hippocampus and cingulate cortex was disrupted, and the length of axons extended by cortical and hippocampal neurons in culture was severely reduced. This indicates that Insr, along with Igf1r, is required for brain development in a region-specific manner and promotes axon growth [2].
In conclusion, Insr is essential for multiple biological functions, with its role in the insulin signaling pathway being of great significance. Studies using gene knockout mouse models, like the Igf1r;Insr knockout, have provided insights into its role in brain development. Understanding Insr's functions may offer potential targets for treating diseases associated with insulin signaling dysregulation.
References:
1. Payankaulam, Sandhya, Raicu, Ana-Maria, Arnosti, David N. 2019. Transcriptional Regulation of INSR, the Insulin Receptor Gene. In Genes, 10, . doi:10.3390/genes10120984. https://pubmed.ncbi.nlm.nih.gov/31795422/
2. Jin, Jing, Ravindran, Priyadarshini, Di Meo, Danila, Püschel, Andreas W. 2019. Igf1R/InsR function is required for axon extension and corpus callosum formation. In PloS one, 14, e0219362. doi:10.1371/journal.pone.0219362. https://pubmed.ncbi.nlm.nih.gov/31318893/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen