C57BL/6NCya-Itga7em1flox/Cya
Common Name:
Itga7-flox
Product ID:
S-CKO-03155
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Itga7-flox
Strain ID
CKOCMP-16404-Itga7-B6N-VA
Gene Name
Product ID
S-CKO-03155
Gene Alias
[a]7; alpha7
Background
C57BL/6NCya
NCBI ID
Modification
Conditional knockout
Chromosome
10
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Itga7em1flox/Cya mice (Catalog S-CKO-03155) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000099112
NCBI RefSeq
NM_008398
Target Region
Exon 2~4
Size of Effective Region
~3.2 kb
Detailed Document
Overview of Gene Research
Itga7, short for Integrin Subunit Alpha 7, is a transmembrane receptor belonging to the integrin family. Integrins play crucial roles in cell-matrix and cell-cell adhesion, as well as in signal transduction pathways that regulate various cellular processes such as cell survival, proliferation, and differentiation [1,2,3,4,5,6,7,8,9,10].
In cancer research, loss-of-function studies have shown significant impacts. In ovarian cancer, ITGA7 loss drives the differentiation of adipose-derived mesenchymal stem cells (ADSCs) to cancer-associated fibroblasts (CAFs), which contribute to a tumor-supportive niche [1]. In colorectal cancer, promoter hypermethylation-induced downregulation of ITGA7 promotes cell proliferation and migration by activating the PI3K/AKT/NF-κB pathway [8]. In breast cancer, knocking down ITGA7 significantly inhibits cell migration and invasion [10]. In cervical cancer, high ITGA7 expression is linked with poor differentiation, lymph node metastasis, and worse survival [4]. In Ph-acute lymphoblastic leukemia, elevated ITGA7 expression is associated with CNS leukemia occurrence, higher bone marrow blasts, lower complete remission rate, and worse prognosis [5]. In Parkinson's disease models, decreased ITGA7 levels are associated with increased α-synuclein levels, suggesting a role in the disease pathology [7,9].
In conclusion, Itga7 has diverse functions in normal biological processes related to cell adhesion and signaling. Through gene knockout or knockdown studies in various disease models, it has been revealed that Itga7 plays important roles in cancer progression, including metastasis and cell differentiation, as well as in Parkinson's disease pathology. Understanding the function of Itga7 provides insights into the mechanisms of these diseases, potentially leading to new therapeutic strategies.
References:
1. Liu, Xiaoli, Gao, Rui, Wu, Qiulei, Li, Min, Wang, Zehua. 2024. ITGA7 loss drives the differentiation of adipose-derived mesenchymal stem cells to cancer-associated fibroblasts. In Molecular carcinogenesis, 63, 479-493. doi:10.1002/mc.23665. https://pubmed.ncbi.nlm.nih.gov/38174862/
2. Liu, Lu-Lin, Xiao, Yao-Sheng, Huang, Wei-Min, Jia, Peng, Liu, Wu-Yang. 2022. ATF1/miR-214-5p/ITGA7 axis promotes osteoclastogenesis to alter OVX-induced bone absorption. In Molecular medicine (Cambridge, Mass.), 28, 56. doi:10.1186/s10020-022-00476-7. https://pubmed.ncbi.nlm.nih.gov/35568813/
3. Li, Wei, Wei, Wancheng, Hu, Dingyin, Tang, Rutong, Hu, Zikang. 2023. circRNA ITGA7 restrains growth and enhances radiosensitivity by up-regulating SMAD4 in colorectal carcinoma. In Open medicine (Warsaw, Poland), 18, 20220604. doi:10.1515/med-2022-0604. https://pubmed.ncbi.nlm.nih.gov/36694626/
4. Yuan, Na, Wang, Lei, Xi, Qiang, Lu, Xiurong, Zhang, Zhilin. 2022. ITGA7, CD133, ALDH1 are inter-correlated, and linked with poor differentiation, lymph node metastasis as well as worse survival in surgical cervical cancer. In The journal of obstetrics and gynaecology research, 48, 1011-1018. doi:10.1111/jog.15163. https://pubmed.ncbi.nlm.nih.gov/35194895/
5. Zhang, Xin, Ke, Shandong, Lu, Yalan, An, Hongyu. 2021. ITGA7 relates to disease risk, pathological feature, treatment response and survival in Ph- acute lymphoblastic leukemia. In Biomarkers in medicine, 15, 1589-1597. doi:10.2217/bmm-2021-0496. https://pubmed.ncbi.nlm.nih.gov/34743543/
6. Yang, Guangpu, Zhang, Tianhao, Ye, Jinning, Cai, Shirong, Ma, Jinping. 2019. Circ-ITGA7 sponges miR-3187-3p to upregulate ASXL1, suppressing colorectal cancer proliferation. In Cancer management and research, 11, 6499-6509. doi:10.2147/CMAR.S203137. https://pubmed.ncbi.nlm.nih.gov/31372051/
7. Han, Sangeun, Lim, Sabina, Yeo, Sujung. 2022. Association between Decreased ITGA7 Levels and Increased Muscle α-Synuclein in an MPTP-Induced Mouse Model of Parkinson's Disease. In International journal of molecular sciences, 23, . doi:10.3390/ijms23105646. https://pubmed.ncbi.nlm.nih.gov/35628462/
8. Wang, Jianjun, Wang, Yu, Zhu, Jijun, Wang, Xiaoyan, Li, Xiaomin. 2024. Promoter hypermethylation-induced downregulation of ITGA7 promotes colorectal cancer proliferation and migration by activating the PI3K/AKT/NF-κB pathway. In Biochimica et biophysica acta. Molecular cell research, 1871, 119785. doi:10.1016/j.bbamcr.2024.119785. https://pubmed.ncbi.nlm.nih.gov/38885843/
9. Han, Sangeun, Seo, Min Hyung, Lim, Sabina, Yeo, Sujung. 2021. Decrease in ITGA7 Levels Is Associated with an Increase in α-Synuclein Levels in an MPTP-Induced Parkinson's Disease Mouse Model and SH-SY5Y Cells. In International journal of molecular sciences, 22, . doi:10.3390/ijms222312616. https://pubmed.ncbi.nlm.nih.gov/34884422/
10. Bhandari, Adheesh, Xia, Erjie, Zhou, Yuying, Wang, Ouchen, Zhang, Xiaohua. 2018. ITGA7 functions as a tumor suppressor and regulates migration and invasion in breast cancer. In Cancer management and research, 10, 969-976. doi:10.2147/CMAR.S160379. https://pubmed.ncbi.nlm.nih.gov/29760566/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen