C57BL/6JCya-Lmnaem1flox/Cya
Common Name:
Lmna-flox
Product ID:
S-CKO-03406
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Lmna-flox
Strain ID
CKOCMP-16905-Lmna-B6J-VA
Gene Name
Product ID
S-CKO-03406
Gene Alias
Dhe
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
3
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Lmnaem1flox/Cya mice (Catalog S-CKO-03406) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000029699
NCBI RefSeq
NM_001002011.3
Target Region
Exon 2~5
Size of Effective Region
~2.8 kb
Detailed Document
Overview of Gene Research
Lmna, which encodes lamin A/C, is a gene crucial for maintaining nuclear mechanostability and function, chromatin organization, and gene transcription as a component of the nuclear envelope [1]. Mutations in Lmna can lead to a variety of diseases known as laminopathies, including LMNA-related cardiomyopathy, a common and highly penetrant inherited heart disease with a poor prognosis [1].
Mouse models have been used to characterize the phenotypic diversity caused by specific Lmna variants and understand the pathogenesis of heart disease. These models have shown that Lmna mutations disrupt nuclear envelope stability, activate the DNA damage response, and compromise chromatin organization and mechanotransduction, leading to fibrosis, arrhythmias, and myocardial remodeling [2].
In conclusion, Lmna is essential for normal nuclear function and its disruption through mutations can lead to severe cardiac phenotypes. The use of mouse models has been instrumental in revealing the role of Lmna in the pathogenesis of LMNA-related cardiomyopathy, highlighting its significance in understanding this inherited heart disease [1,2].
References:
1. Wang, Yinuo, Dobreva, Gergana. 2023. Epigenetics in LMNA-Related Cardiomyopathy. In Cells, 12, . doi:10.3390/cells12050783. https://pubmed.ncbi.nlm.nih.gov/36899919/
2. Rouhi, Leila. 2025. Cardiac phenotypes in LMNA mutations. In Current opinion in cardiology, 40, 131-138. doi:10.1097/HCO.0000000000001209. https://pubmed.ncbi.nlm.nih.gov/39998502/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen