C57BL/6JCya-Parvbem1flox/Cya
Common Name
Parvb-flox
Product ID
S-CKO-03493
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-170736-Parvb-B6J-VA
Status
When using this mouse strain in a publication, please cite “Parvb-flox Mouse (Catalog S-CKO-03493) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Parvb-flox
Strain ID
CKOCMP-170736-Parvb-B6J-VA
Gene Name
Product ID
S-CKO-03493
Gene Alias
D15Gsk1, affixin
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 15
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000023072
NCBI RefSeq
NM_133167
Target Region
Exon 4
Size of Effective Region
~0.6 kb
Overview of Gene Research
Parvb, also known as beta-parvin, is an actin-binding and focal adhesion protein. It is involved in linking integrins and associated proteins with intracellular pathways that regulate actin cytoskeletal dynamics and cell survival. The ILK-β-parvin pathway, where Parvb is a part, can enhance cell motility [2].
In a mouse model (PARVB cKO) where the Parvb gene was specifically deleted from proximal tubular epithelial cells, depletion of Parvb significantly attenuated cisplatin-induced renal tubular injury, including tubular cell death and inflammation. Mechanistically, Parvb associates with TAK1, and depletion of Parvb promotes cisplatin-induced TAK1 degradation, inhibits TAK1 downstream signaling, and alleviates cisplatin-induced tubular cell damage [1].
In conclusion, Parvb plays a crucial role in cell adhesion, spreading, motility, and survival. The study of Parvb cKO mouse models reveals its significance in cisplatin-induced renal tubular injury, suggesting that targeting the Parvb-TAK1 pathway may offer a novel therapeutic strategy for alleviating cisplatin-induced kidney damage.
References：
1. Yang, Aihua, Ding, Yanyan, Guo, Chen, Wu, Chuanyue, Sun, Ying. 2024. PARVB deficiency alleviates cisplatin-induced tubular injury by inhibiting TAK1 signaling. In Cellular and molecular life sciences : CMLS, 81, 385. doi:10.1007/s00018-024-05422-w. https://pubmed.ncbi.nlm.nih.gov/39235496/
2. Sepulveda, J L, Wu, C. . The parvins. In Cellular and molecular life sciences : CMLS, 63, 25-35. doi:. https://pubmed.ncbi.nlm.nih.gov/16314921/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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