Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Madcam1em1flox/Cya
Common Name:
Madcam1-flox
Product ID:
S-CKO-03576
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Madcam1-flox
Strain ID
CKOCMP-17123-Madcam1-B6J-VA
Gene Name
Madcam1
Product ID
S-CKO-03576
Gene Alias
MAdCAM-1
Background
C57BL/6JCya
NCBI ID
17123
Modification
Conditional knockout
Chromosome
10
Phenotype
MGI:103579
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Madcam1em1flox/Cya mice (Catalog S-CKO-03576) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000020554
NCBI RefSeq
NM_013591
Target Region
Exon 1~4
Size of Effective Region
~3.0 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Madcam1, also known as mucosal addressin cell adhesion molecule 1, is a crucial adhesion molecule. It plays a vital role in lymphocyte homing, especially in the gut-associated lymphoid tissue, by interacting with its receptor α4β7 integrin. This interaction is involved in regulating immunity and inflammation processes. The NKX-COUP-TFII morphogenetic code has been identified to direct its expression [6].

In various disease models, Madcam1 has shown significant effects. In cancer, post-antibiotics gut recolonization by Enterocloster species down-regulates ileum Madcam1, leading to the emigration of enterotropic α4β7+CD4+ regulatory T 17 cells into the tumor, indicating its role in cancer immunosurveillance [1]. In colitis, optogenetic activation of local colonic sympathetic innervations reduces endothelial MAdCAM-1 expression, attenuating experimental colitis and immune cell extravasation [2]. In acute liver failure, MAdCAM1 levels are induced and positively correlated with liver damage; activating the cholinergic anti-inflammatory pathway down-regulates MAdCAM1, alleviating liver injury [3]. In glaucoma, MAdCAM-1 is induced in retinal endothelial cells by elevated intraocular pressure, and its neutralization ameliorates retinal ganglion cell loss [4]. In Crohn's disease, treatment with anti-TNF-α reduces the number of MAdCAM-1-positive mucosal capillaries [5]. In checkpoint inhibitor colitis, endothelial cells upregulate MAdCAM-1, which may respond to vedolizumab [7].

In conclusion, Madcam1 is essential for lymphocyte homing and immune-related processes. Studies using gene-related models, such as those in cancer, colitis, liver failure, glaucoma, Crohn's disease, and checkpoint inhibitor colitis, have revealed its role in disease-associated inflammation, immune cell trafficking, and disease progression. Understanding Madcam1 can potentially provide new therapeutic targets for these diseases.

References:
1. Fidelle, Marine, Rauber, Conrad, Alves Costa Silva, Carolina, Kroemer, Guido, Zitvogel, Laurence. 2023. A microbiota-modulated checkpoint directs immunosuppressive intestinal T cells into cancers. In Science (New York, N.Y.), 380, eabo2296. doi:10.1126/science.abo2296. https://pubmed.ncbi.nlm.nih.gov/37289890/
2. Schiller, Maya, Azulay-Debby, Hilla, Boshnak, Nadia, Hakim, Fahed, Rolls, Asya. 2021. Optogenetic activation of local colonic sympathetic innervations attenuates colitis by limiting immune cell extravasation. In Immunity, 54, 1022-1036.e8. doi:10.1016/j.immuni.2021.04.007. https://pubmed.ncbi.nlm.nih.gov/33932356/
3. Fu, Shan, Ni, TianZhi, Zhang, MengMeng, Zhao, YingRen, Liu, JinFeng. 2023. Cholinergic Anti-inflammatory Pathway Attenuates Acute Liver Failure Through Inhibiting MAdCAM1/α4β7-mediated Gut-derived Proinflammatory Lymphocytes Accumulation. In Cellular and molecular gastroenterology and hepatology, 17, 199-217. doi:10.1016/j.jcmgh.2023.10.012. https://pubmed.ncbi.nlm.nih.gov/37926366/
4. He, Chong, Xiu, Wenbo, Chen, Qinyuan, Yu, Ling, Lu, Fang. 2023. Gut-licensed β7+ CD4+ T cells contribute to progressive retinal ganglion cell damage in glaucoma. In Science translational medicine, 15, eadg1656. doi:10.1126/scitranslmed.adg1656. https://pubmed.ncbi.nlm.nih.gov/37531415/
5. Younes, Mamoun, DuPont, Andrew W, Cash, Brooks D, Ertan, Atilla. . Alterations in MAdCAM1-Positive Mucosal Capillaries and Integrin a4b7-Positive Lymphocytes in Crohn's Disease Treated with Anti-TNFα Biologics. In Annals of clinical and laboratory science, 51, 678-685. doi:. https://pubmed.ncbi.nlm.nih.gov/34686510/
6. Dinh, Thanh Theresa, Xiang, Menglan, Rajaraman, Anusha, Pan, Junliang, Butcher, Eugene C. 2022. An NKX-COUP-TFII morphogenetic code directs mucosal endothelial addressin expression. In Nature communications, 13, 7448. doi:10.1038/s41467-022-34991-2. https://pubmed.ncbi.nlm.nih.gov/36460642/
7. He, Jun Yan, Kim, Yang-Joon, Mennillo, Elvira, Kattah, Michael G, Oh, David Y. 2024. Dysregulation of CD4+ and CD8+ resident memory T, myeloid, and stromal cells in steroid-experienced, checkpoint inhibitor colitis. In Journal for immunotherapy of cancer, 12, . doi:10.1136/jitc-2023-008628. https://pubmed.ncbi.nlm.nih.gov/38642938/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest