C57BL/6JCya-Foxd2em1flox/Cya
Common Name
Foxd2-flox
Product ID
S-CKO-03720
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-17301-Foxd2-B6J-VA
Status
When using this mouse strain in a publication, please cite “Foxd2-flox Mouse (Catalog S-CKO-03720) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Foxd2-flox
Strain ID
CKOCMP-17301-Foxd2-B6J-VA
Gene Name
Product ID
S-CKO-03720
Gene Alias
Mf2
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 4
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000068654
NCBI RefSeq
NM_008593
Target Region
Exon 1
Size of Effective Region
~3.4 kb
Overview of Gene Research
Foxd2, a member of the Forkhead box (FOX) gene family, is a transcriptional factor closely associated with apoptosis, proliferation, and other cellular processes [1]. It is involved in the regulation of genes and pathways that are crucial for normal cellular function and development.
In gastric adenocarcinoma, FOXD2 shows high expression in tissues and cells. Silencing FOXD2 considerably attenuates cell proliferation. It was found that FOXD2 promotes gastric adenocarcinoma cell proliferation by transcriptionally activating its downstream target gene IQGAP3, which leads to an increase in the intracellular Ca2+ level [1].
In conclusion, Foxd2 is a significant transcriptional factor involved in important cellular processes. Its role in promoting the proliferation of gastric adenocarcinoma cells through the IQGAP3-mediated Ca2+ signaling pathway reveals its importance in cancer-related research. Understanding Foxd2's function may provide new insights into the mechanisms of gastric adenocarcinoma development and potential therapeutic strategies.
References：
1. Fei, Ting, Zhou, En-Cheng, Wang, Xiao-Jun. 2023. FOXD2 regulations IQGAP3 mediated Ca2+ signaling pathway to facilitate gastric adenocarcinoma cell promotion. In The Kaohsiung journal of medical sciences, 39, 1087-1095. doi:10.1002/kjm2.12756. https://pubmed.ncbi.nlm.nih.gov/37724892/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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