C57BL/6JCya-Mmp3em1flox/Cya
Common Name:
Mmp3-flox
Product ID:
S-CKO-03756
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Mmp3-flox
Strain ID
CKOCMP-17392-Mmp3-B6J-VA
Gene Name
Product ID
S-CKO-03756
Gene Alias
EMS-2; MMP-3; SL-1; SLN-1; SLN1; STR-1; Stmy1; Str1
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
9
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Mmp3em1flox/Cya mice (Catalog S-CKO-03756) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000034497
NCBI RefSeq
NM_010809
Target Region
Exon 2~4
Size of Effective Region
~1.2 kb
Detailed Document
Overview of Gene Research
Mmp3, also known as stromelysin-1, is an enzyme belonging to the matrix metalloproteinase family. It plays a crucial role in degrading the extracellular matrix, which is important for normal physiological processes such as tissue remodeling and cell migration. It is also involved in inflammatory pathways, like those related to tumor necrosis factor-alpha (TNF-α) and NF-κB [3].
Mmp3 has been implicated in several diseases. In rheumatoid arthritis (RA), serum levels of MMP3 positively reflect disease activity, joint and bone injury, radiological erosion, and can predict disease outcome and drug responsiveness, suggesting it could be used in personalized medical management of RA [1]. In severe COVID-19, it has been investigated as a diagnostic biomarker and potential therapeutic target [2]. For ankylosing spondylitis (AS), it contributes to both joint destruction and the progression of cardiovascular diseases by degrading the extracellular matrix and destabilizing atherosclerotic plaques, indicating that its inhibition could be a therapeutic strategy to reduce cardiovascular risk in AS patients [3]. In familial Mediterranean fever (FMF), MMP3 levels are significantly higher during attacks compared to healthy controls, which might aid in diagnosing FMF attacks [4]. In the context of cerebral stroke, certain gene polymorphisms of MMP3 are associated with the risk of ischemic and hemorrhagic stroke in the Chinese Han population [5]. In skin-bearing vascularized composite allotransplantation, serum MMP3 protein is a promising marker for stratifying patients according to the severity of rejection [6].
In conclusion, Mmp3 is essential for extracellular matrix degradation and is involved in multiple disease-related processes. Research on Mmp3, especially through genetic models in relevant diseases, provides valuable insights into disease mechanisms and potential therapeutic strategies for conditions like RA, COVID-19, AS, FMF, cerebral stroke, and allotransplant rejection.
References:
1. Lerner, Aaron, Neidhöfer, Sandra, Reuter, Sandra, Matthias, Torsten. 2019. MMP3 is a reliable marker for disease activity, radiological monitoring, disease outcome predictability, and therapeutic response in rheumatoid arthritis. In Best practice & research. Clinical rheumatology, 32, 550-562. doi:10.1016/j.berh.2019.01.006. https://pubmed.ncbi.nlm.nih.gov/31174824/
2. Almuntashiri, Sultan, Zhang, Duo, Somanath, Payaningal R, Sikora, Andrea. . MMP3 in Severe COVID-19: A Biomarker or Therapeutic Target? In Infectious disorders drug targets, 23, e190622206159. doi:10.2174/1871526522666220619121539. https://pubmed.ncbi.nlm.nih.gov/35726419/
3. Roa-Bruzón, Iliannis Y, Duany-Almira, Luis F, Valle-Delgadillo, Yeminia M, Valdés-Alvarado, Emmanuel, Padilla-Gutiérrez, Jorge R. 2025. MMP3 as a Molecular Link: Unraveling the Connection Between Ankylosing Spondylitis and Acute Coronary Syndrome. In Cells, 14, . doi:10.3390/cells14080597. https://pubmed.ncbi.nlm.nih.gov/40277922/
4. Kilinc, Ozgur C, Akdeniz, Yonca S, Taskin, Zuleyha, Can, Gunay, Ugurlu, Serdal. . Exploring S100A8/A9, neopterin, and MMP3 in familial Mediterranean fever. In Clinical and experimental immunology, 218, 93-100. doi:10.1093/cei/uxae049. https://pubmed.ncbi.nlm.nih.gov/38864482/
5. Yin, Yanling, Zhang, Yu, Zhang, Xiaobo, Shi, Wenzhen, Tian, Ye. 2023. Association of MMP3, MMP14, and MMP25 gene polymorphisms with cerebral stroke risk: a case-control study. In BMC medical genomics, 16, 297. doi:10.1186/s12920-023-01734-1. https://pubmed.ncbi.nlm.nih.gov/37986083/
6. Kollar, Branislav, Uffing, Audrey, Borges, Thiago J, Pomahac, Bohdan, Riella, Leonardo V. 2019. MMP3 Is a Non-invasive Biomarker of Rejection in Skin-Bearing Vascularized Composite Allotransplantation: A Multicenter Validation Study. In Frontiers in immunology, 10, 2771. doi:10.3389/fimmu.2019.02771. https://pubmed.ncbi.nlm.nih.gov/31849957/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen