C57BL/6JCya-Foxk1em1flox/Cya
Common Name:
Foxk1-flox
Product ID:
S-CKO-03762
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Foxk1-flox
Strain ID
CKOCMP-17425-Foxk1-B6J-VA
Gene Name
Product ID
S-CKO-03762
Gene Alias
A630048H08Rik; Gm10868; Mnf
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
5
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Foxk1em1flox/Cya mice (Catalog S-CKO-03762) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000072837
NCBI RefSeq
NM_199068
Target Region
Exon 3
Size of Effective Region
~1.6 kb
Detailed Document
Overview of Gene Research
Foxk1, a forkhead/winged helix transcription factor, is involved in regulating various cellular processes such as cell proliferation, differentiation, and metabolism. It is associated with pathways like Wnt/β -catenin, mTORC1, and aerobic glycolysis, and is of great biological importance in development and disease [3,4,6]. Genetic models, especially KO and CKO mouse models, have been crucial for studying its functions.
In KO mouse models, conditional knockout of Foxk1 in preosteoblasts and mature osteoblasts led to decreased bone mass and mechanical strength due to reduced bone formation, as it was found to target the promoter region of glycolytic enzyme genes and regulate aerobic glycolysis in osteoblasts [1]. Hepatocyte-specific deletion of Foxk1 in mice fed a NASH-inducing diet ameliorated hepatic steatosis, inflammation, fibrosis, and tumorigenesis [2]. Cardiomyocyte-specific knockout of Foxk1 impaired neonatal heart regeneration after myocardial infarction injury [5].
In conclusion, Foxk1 plays vital roles in osteoblast metabolism regulation, hepatic lipid metabolism, and cardiogenesis. Its study using KO and CKO mouse models has provided insights into age-related bone loss, non-alcoholic fatty liver disease, and congenital heart disease, highlighting its potential as a therapeutic target in these disease areas.
References:
1. Liu, Chungeng, Feng, Naibo, Wang, Zhenmin, Long, Houqing, Peng, Songlin. 2024. Foxk1 promotes bone formation through inducing aerobic glycolysis. In Cell death and differentiation, 31, 1650-1663. doi:10.1038/s41418-024-01371-w. https://pubmed.ncbi.nlm.nih.gov/39232134/
2. Fujinuma, Shun, Nakatsumi, Hirokazu, Shimizu, Hideyuki, Ohkawa, Yasuyuki, Nakayama, Keiichi I. 2023. FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation. In Cell reports, 42, 112530. doi:10.1016/j.celrep.2023.112530. https://pubmed.ncbi.nlm.nih.gov/37209098/
3. Sierra-Pagan, Javier E, Dsouza, Nikita, Das, Satyabrata, Gong, Wuming, Garry, Daniel J. . FOXK1 regulates Wnt signalling to promote cardiogenesis. In Cardiovascular research, 119, 1728-1739. doi:10.1093/cvr/cvad054. https://pubmed.ncbi.nlm.nih.gov/37036809/
4. Sukonina, Valentina, Ma, Haixia, Zhang, Wei, Kanduri, Chandrasekhar, Enerbäck, Sven. 2019. FOXK1 and FOXK2 regulate aerobic glycolysis. In Nature, 566, 279-283. doi:10.1038/s41586-019-0900-5. https://pubmed.ncbi.nlm.nih.gov/30700909/
5. Cai, Dongcheng, Liu, Chungeng, Li, Haotong, Zhang, Yuhui, Nie, Yu. 2025. Foxk1 and Foxk2 promote cardiomyocyte proliferation and heart regeneration. In Nature communications, 16, 2877. doi:10.1038/s41467-025-57996-z. https://pubmed.ncbi.nlm.nih.gov/40128196/
6. Sakaguchi, Masaji, Cai, Weikang, Wang, Chih-Hao, Enerbäck, Sven, Kahn, C Ronald. 2019. FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism. In Nature communications, 10, 1582. doi:10.1038/s41467-019-09418-0. https://pubmed.ncbi.nlm.nih.gov/30952843/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen