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C57BL/6JCya-Mtnr1aem1flox/Cya
Common Name:
Mtnr1a-flox
Product ID:
S-CKO-03826
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Price:
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Basic Information
Strain Name
Mtnr1a-flox
Strain ID
CKOCMP-17773-Mtnr1a-B6J-VA
Gene Name
Mtnr1a
Product ID
S-CKO-03826
Gene Alias
MR; MelR
Background
C57BL/6JCya
NCBI ID
17773
Modification
Conditional knockout
Chromosome
8
Phenotype
MGI:102967
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Mtnr1aem1flox/Cya mice (Catalog S-CKO-03826) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000067984
NCBI RefSeq
NM_008639
Target Region
Exon 2
Size of Effective Region
~2.0 kb
Detailed Document
Click here to download >>
Overview of Gene Research
MTNR1A, encoding the melatonin receptor 1A, is a crucial gene involved in various biological functions. Melatonin, by binding to MTNR1A, regulates the mammalian circadian rhythm, glucose homeostasis, and reproductive activities. It is also associated with pathways related to cyclic adenosine monophosphate-responsive element-binding protein phosphorylation [1,2,4].

In renal tubular cells, cytoplasmic heterogeneous nuclear ribonucleoprotein L (hnRNPL) post-transcriptionally upregulates MTNR1A RNA through CA-repeat elements in its coding region, protecting it from degradation by exosome component 10 protein. MTNR1A shows a diurnal rhythm in mouse kidneys, with enhanced levels at midnight [1]. In Italian families, three novel variants of MTNR1A were significantly linked to and/or associated with type 2 diabetes [2]. In different Mediterranean sheep breeds, SNPs in the MTNR1A gene exon II affected reproductive performance, such as fertility rate and the duration from ram placement to lambing [3]. In Tibetan sheep, MTNR1A was distributed in the hypothalamus-pituitary-gonadal axis, and its expression in this axis during the estrous cycle was related to the secretion of melatonin and steroid hormones [4]. In buffalo, the expression of MTNR1A in ovarian follicles decreased with the increasing size of the follicle and intrafollicular melatonin concentration, indicating a possible role in folliculogenesis and ovulation [5]. In Tunisian sheep breeds, SNPs in the MTNR1A gene were associated with reproductive performance parameters like birth weight [6].

In conclusion, MTNR1A is essential for regulating circadian rhythms, glucose metabolism, and reproductive functions. Studies on MTNR1A, especially through genetic polymorphism and expression analysis in various animal models, contribute to understanding its role in diseases such as type 2 diabetes and its importance in reproductive regulation in livestock.

References:
1. Huang, Yen-Sung, Lu, Kuo-Cheng, Chao, Hsu-Wen, Sytwu, Huey-Kang, Wu, Chia-Chao. 2020. The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells. In Journal of cellular physiology, 236, 2023-2035. doi:10.1002/jcp.29988. https://pubmed.ncbi.nlm.nih.gov/32730662/
2. Amin, M, Gragnoli, C. . Melatonin receptor 1A (MTNR1A) gene linkage and association to type 2 diabetes in Italian families. In European review for medical and pharmacological sciences, 27, 4688-4692. doi:10.26355/eurrev_202305_32480. https://pubmed.ncbi.nlm.nih.gov/37259752/
3. Pulinas, L, Starič, J, Cosso, G, Carcangiu, V, Luridiana, S. 2021. MTNR1A gene polymorphisms and reproductive recovery after seasonal anoestrus in different Mediterranean sheep breeds. In Animal reproduction science, 236, 106905. doi:10.1016/j.anireprosci.2021.106905. https://pubmed.ncbi.nlm.nih.gov/34922186/
4. Yang, Dapeng, He, Yuqin, Yuan, Ligang, Zhou, Kairen, Bao, Yingying. 2022. Expression and distribution of MTNR1A in the hypothalamus-pituitary-gonadal axis of Tibetan sheep during the estrous cycle. In Gene, 839, 146731. doi:10.1016/j.gene.2022.146731. https://pubmed.ncbi.nlm.nih.gov/35835405/
5. Soni, N, Pandey, A K, Kumar, A, Kumar, V, Singh, V. 2019. Expression of MTNR1A, steroid (ERα, ERβ, and PR) receptor gene transcripts, and the concentration of melatonin and steroid hormones in the ovarian follicles of buffalo. In Domestic animal endocrinology, 72, 106371. doi:10.1016/j.domaniend.2019.06.003. https://pubmed.ncbi.nlm.nih.gov/31421986/
6. Arjoune, Asma, Alsaleh, Abrar B, Messaoudi, Safia A, Haddad, Brahim, Sirard, Marc-André. 2023. Analysis of MTNR1A Genetic Polymorphisms and Their Association with the Reproductive Performance Parameters in Two Mediterranean Sheep Breeds. In Animals : an open access journal from MDPI, 13, . doi:10.3390/ani13030448. https://pubmed.ncbi.nlm.nih.gov/36766337/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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