C57BL/6NCya-Mvkem1flox/Cya
Common Name:
Mvk-flox
Product ID:
S-CKO-03839
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Mvk-flox
Strain ID
CKOCMP-17855-Mvk-B6N-VA
Gene Name
Product ID
S-CKO-03839
Gene Alias
2310010A05Rik; MK
Background
C57BL/6NCya
NCBI ID
Modification
Conditional knockout
Chromosome
5
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Mvkem1flox/Cya mice (Catalog S-CKO-03839) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000043760
NCBI RefSeq
NM_023556
Target Region
Exon 4~5
Size of Effective Region
~1.1 kb
Detailed Document
Overview of Gene Research
Mvk, short for mevalonate kinase, is an enzyme involved in the mevalonate pathway, a key metabolic route for the synthesis of cholesterol and other isoprenoids [2,4]. This pathway is essential for multiple cellular functions, including cell growth, membrane synthesis, and protein prenylation.
Mutations in the MVK gene are associated with mevalonate kinase deficiency, an autosomal recessive auto-inflammatory disease [2,4]. The clinical spectrum ranges from the milder hyperimmunoglobulinemia D with periodic fever syndrome to the more severe mevalonate aciduria [4]. In addition, MVK mutations have been linked to skin disorders such as linear porokeratosis [1], porokeratosis of Mibelli [5], and disseminated superficial porokeratosis [6]. In lung adenocarcinoma, MVK, induced by Kras, represses cGAS-Sting signalling, modifying the immunological milieu [3].
In conclusion, Mvk is crucial for the mevalonate pathway and its associated functions. Research on MVK mutations in various disease models has revealed its significant role in auto-inflammatory diseases and skin disorders. Understanding Mvk's functions in these disease contexts may provide new therapeutic targets for treatment [1,2,3,4,5,6].
References:
1. Zhao, Anqi, Wang, Xinyi, Pan, Chaolan, Li, Min, Li, Ming. 2024. Epidermal second-hit mutation in MVK gene associated with linear porokeratosis. In Genes & diseases, 12, 101314. doi:10.1016/j.gendis.2024.101314. https://pubmed.ncbi.nlm.nih.gov/39386107/
2. Georgin-Lavialle, Sophie, Ducharme-Benard, Stéphanie, Sarrabay, Guillaume, Grateau, Gilles, Hentgen, Véronique. 2020. Systemic autoinflammatory diseases: Clinical state of the art. In Best practice & research. Clinical rheumatology, 34, 101529. doi:10.1016/j.berh.2020.101529. https://pubmed.ncbi.nlm.nih.gov/32546426/
3. Zhou, Changsheng, Liu, Jia, Hu, Xudong, Liu, Yiqian, Huang, Yufeng. 2025. MVK, induced by Kras, represses cGAS-Sting signalling in lung adenocarcinoma. In European journal of medical research, 30, 43. doi:10.1186/s40001-024-02186-8. https://pubmed.ncbi.nlm.nih.gov/39844257/
4. Galeotti, Caroline. . [Mevalonate kinase deficiency]. In La Revue du praticien, 73, 850-854. doi:. https://pubmed.ncbi.nlm.nih.gov/38354005/
5. Zeng, Kang, Zhang, Qi-Guo, Li, Li, Duan, Yan, Liang, Yan-Hua. 2014. Splicing mutation in MVK is a cause of porokeratosis of Mibelli. In Archives of dermatological research, 306, 749-55. doi:10.1007/s00403-014-1465-7. https://pubmed.ncbi.nlm.nih.gov/24781643/
6. Hui, Hai-Zhen, Wang, Ying-Jun, Cheng, Jia-Rong, Guo, Hong-Xing, Shi, Bing-Jun. 2022. A novel missense mutation in the MVK gene is associated with disseminated superficial porokeratosis. In International journal of dermatology, 62, e223-e225. doi:10.1111/ijd.16493. https://pubmed.ncbi.nlm.nih.gov/36371681/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen