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C57BL/6JCya-Mybl2em1flox/Cya
Common Name:
Mybl2-flox
Product ID:
S-CKO-03844
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Mybl2-flox
Strain ID
CKOCMP-17865-Mybl2-B6J-VA
Gene Name
Mybl2
Product ID
S-CKO-03844
Gene Alias
B-Myb; Bmyb
Background
C57BL/6JCya
NCBI ID
17865
Modification
Conditional knockout
Chromosome
2
Phenotype
MGI:101785
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Mybl2em1flox/Cya mice (Catalog S-CKO-03844) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000018005
NCBI RefSeq
NM_008652
Target Region
Exon 5
Size of Effective Region
~0.7 kb
Detailed Document
Click here to download >>
Overview of Gene Research
MYBL2, also known as B-MYB, is a transcription factor of the MYB transcription factor family. It is essential for regulating vital cellular processes such as cell proliferation, differentiation, DNA repair, and cell cycle progression [1,3]. It also plays a role in cell survival and is involved in the regulation of many biological pathways, the deregulation of which can contribute to cancer development [3]. Genetic models, like KO/CKO mouse models, are valuable for studying MYBL2's functions.

In cancer research, loss-of-function experiments have shown significant impacts. In bladder cancer, MYBL2 deficiency suppressed cell proliferation and migration both in vitro and in vivo, revealing it as an oncogene that accelerates cancer progression through transactivation of CDCA3 [2]. In prostate cancer, genetic inhibition of Mybl2 in murine models representing phenotypic plasticity decreased in vivo growth, cell fitness, and repressed gene signatures related to pluripotency and stemness [4]. In ovarian cancer, targeting the MYBL2-ATAD2 axis by Nuclease technology-mediated ATAD2 ablation inhibited in vivo tumor growth in a xenograft mouse model, highlighting this axis's role in cell proliferation [5].

In conclusion, MYBL2 is a central regulator of cell proliferation, survival, and differentiation. Through model-based research, especially KO/CKO mouse models, its crucial role in cancer development and progression in various cancer types, including bladder, prostate, and ovarian cancer, has been revealed. Understanding MYBL2's functions provides potential therapeutic targets for treating these cancers.

References:
1. Bayley, Rachel, Ward, Ciara, Garcia, Paloma. 2020. MYBL2 amplification in breast cancer: Molecular mechanisms and therapeutic potential. In Biochimica et biophysica acta. Reviews on cancer, 1874, 188407. doi:10.1016/j.bbcan.2020.188407. https://pubmed.ncbi.nlm.nih.gov/32853735/
2. Liu, Wei, Shen, Dexin, Ju, Lingao, Xiao, Yu, Wang, Xinghuan. 2022. MYBL2 promotes proliferation and metastasis of bladder cancer through transactivation of CDCA3. In Oncogene, 41, 4606-4617. doi:10.1038/s41388-022-02456-x. https://pubmed.ncbi.nlm.nih.gov/36071275/
3. Musa, Julian, Aynaud, Marie-Ming, Mirabeau, Olivier, Delattre, Olivier, Grünewald, Thomas Gp. 2017. MYBL2 (B-Myb): a central regulator of cell proliferation, cell survival and differentiation involved in tumorigenesis. In Cell death & disease, 8, e2895. doi:10.1038/cddis.2017.244. https://pubmed.ncbi.nlm.nih.gov/28640249/
4. German, Beatriz, Alaiwi, Sarah A, Ho, Kun-Lin, Lawrenson, Kate, Ellis, Leigh. . MYBL2 Drives Prostate Cancer Plasticity: Inhibiting Its Transcriptional Target CDK2 for RB1-Deficient Neuroendocrine Prostate Cancer. In Cancer research communications, 4, 2295-2307. doi:10.1158/2767-9764.CRC-24-0069. https://pubmed.ncbi.nlm.nih.gov/39113611/
5. Liu, Qun, Liu, Heshu, Huang, Xuying, Miao, Jinwei, Liu, Jian. 2022. A targetable MYBL2-ATAD2 axis governs cell proliferation in ovarian cancer. In Cancer gene therapy, 30, 192-208. doi:10.1038/s41417-022-00538-2. https://pubmed.ncbi.nlm.nih.gov/36151333/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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