C57BL/6JCya-Npy1rem1flox/Cya
Common Name
Npy1r-flox
Product ID
S-CKO-04014
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-18166-Npy1r-B6J-VA
When using this mouse strain in a publication, please cite “Npy1r-flox Mouse (Catalog S-CKO-04014) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Npy1r-flox
Strain ID
CKOCMP-18166-Npy1r-B6J-VA
Gene Name
Product ID
S-CKO-04014
Gene Alias
Npyr, Y1-R, NPY1-R
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 8
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000039303
NCBI RefSeq
NM_010934
Target Region
Exon 2~3
Size of Effective Region
~1.5 kb
Overview of Gene Research
Npy1r, encoding the neuropeptide Y Y1 receptor, is a G protein-coupled receptor. Neuropeptide Y (NPY) binding to Npy1r is involved in multiple biological processes. NPY/Npy1r signaling is associated with pathways related to pain regulation, energy homeostasis, and cell growth regulation, among others. Genetic models, such as knockout (KO) and conditional knockout (CKO) mouse models, have been crucial for studying its functions [1-10].
In mouse models, conditional deletion of Npy1r from certain interneurons in the spinal dorsal horn affected neuropathic hypersensitivity, indicating that Grp/Npy1r-INs are key for neuropathic pain treatment [1]. In pancreatic cancer mouse models, pancreas-specific and whole-body knockout of Npy1r significantly decreased liver metastasis, showing that NPY/Npy1r signaling is an antimetastatic target [3]. Conditional inactivation of Npy1r in excitatory neurons of the brain limbic system in mice induced sex-related differences in metabolic and behavioral functions [2].
In conclusion, Npy1r is essential in regulating pain, energy metabolism, cell growth, and metastasis. Studies using KO and CKO mouse models have provided valuable insights into its role in neuropathic pain, pancreatic cancer, and sex-related metabolic and behavioral differences. These findings may contribute to the development of new therapeutic strategies for related diseases.
References：
1. Nelson, Tyler S, Allen, Heather N, Basu, Paramita, Todd, Andrew J, Taylor, Bradley K. 2023. Alleviation of neuropathic pain with neuropeptide Y requires spinal Npy1r interneurons that coexpress Grp. In JCI insight, 8, . doi:10.1172/jci.insight.169554. https://pubmed.ncbi.nlm.nih.gov/37824208/
2. Bertocchi, Ilaria, Oberto, Alessandra, Longo, Angela, Palanza, Paola, Eva, Carola. 2020. Conditional inactivation of Npy1r gene in mice induces sex-related differences of metabolic and behavioral functions. In Hormones and behavior, 125, 104824. doi:10.1016/j.yhbeh.2020.104824. https://pubmed.ncbi.nlm.nih.gov/32755609/
3. Chambers, Cecilia R, Watakul, Supitchaya, Schofield, Peter, Timpson, Paul, Herrmann, David. 2025. Targeting the NPY/NPY1R signaling axis in mutant p53-dependent pancreatic cancer impairs metastasis. In Science advances, 11, eadq4416. doi:10.1126/sciadv.adq4416. https://pubmed.ncbi.nlm.nih.gov/40073121/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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