C57BL/6JCya-Npy6rem1flox/Cya
Common Name
Npy6r-flox
Product ID
S-CKO-04017
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-18169-Npy6r-B6J-VA
When using this mouse strain in a publication, please cite “Npy6r-flox Mouse (Catalog S-CKO-04017) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Npy6r-flox
Strain ID
CKOCMP-18169-Npy6r-B6J-VA
Gene Name
Product ID
S-CKO-04017
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 18
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000042747
NCBI RefSeq
NM_010935
Target Region
Exon 2
Size of Effective Region
~2.6 kb
Overview of Gene Research
Npy6r, a member of the neuropeptide Y receptor family, is involved in multiple physiological functions. It is known to be associated with the regulation of energy homeostasis, and is expressed in neurons where it can participate in various signaling pathways [1].
In Npy6r-deficient (Npy6r(-/-)) mice, there are significant impacts on body composition. Young Npy6r(-/-) mice have reduced body weight, lean mass, and adiposity, while older and high-fat-fed Npy6r(-/-) mice show low lean mass with increased adiposity. This is likely due to impaired vasoactive intestinal peptide (VIP) signaling in the suprachiasmatic nucleus (SCN), as Npy6r is co-expressed in VIP neurons. Pancreatic polypeptide (PP)-initiated signaling through Npy6r in VIP neurons regulates the growth hormone axis and body composition, as peripheral administration of PP has different effects on WT and Npy6r(-/-) mice in terms of energy expenditure, food intake, hypothalamic Ghrh mRNA expression, and serum IGF-1 levels [1].
In conclusion, Npy6r plays a crucial role in regulating energy homeostasis and body composition, as demonstrated by gene knockout mouse models. Understanding its function provides insights into the mechanisms underlying metabolic regulation and potentially related metabolic diseases [1].
References：
1. Yulyaningsih, Ernie, Loh, Kim, Lin, Shu, Sainsbury, Amanda, Herzog, Herbert. . Pancreatic polypeptide controls energy homeostasis via Npy6r signaling in the suprachiasmatic nucleus in mice. In Cell metabolism, 19, 58-72. doi:10.1016/j.cmet.2013.11.019. https://pubmed.ncbi.nlm.nih.gov/24411939/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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