C57BL/6JCya-Ntrk3em1flox/Cya
Common Name
Ntrk3-flox
Product ID
S-CKO-04046
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-18213-Ntrk3-B6J-VA
Status
When using this mouse strain in a publication, please cite “Ntrk3-flox Mouse (Catalog S-CKO-04046) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Ntrk3-flox
Strain ID
CKOCMP-18213-Ntrk3-B6J-VA
Gene Name
Product ID
S-CKO-04046
Gene Alias
TrkC, Ntrk3_tv3
Background
C57BL/6JCya
Gene Full Name
neurotrophic tyrosine kinase, receptor, type 3
Modification
Conditional knockout
NCBI ID
Phenotype
Chromosome
Chr 7 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000039431
NCBI Transcript ID
NM_008746
Target Region
Exon 5
Size of Effective Region
~2.5 kb
Overview of Gene Research
Ntrk3, also known as the neurotrophin-3 receptor, encodes a protein tyrosine kinase. It is involved in multiple signaling cascades, such as the Ras-MAP kinase and PI3K-AKT pathways through the IRS-1 adapter protein [4]. Ntrk3 has pleiotropic functions, acting as an oncogene in some cancers like breast and gastric cancers, and as a dependence receptor in tumor suppressor genes in colon cancer and neuroblastomas [6]. It also plays a role in the regulation of gonadotrope cell adhesion and motility through the Neurod1/4-Ntrk3-cSrc pathway [8].
Ntrk3 gene fusions are oncogenic drivers in various cancers. The ETV6-Ntrk3 (TEL-TRKC) gene fusion, associated with congenital fibrosarcoma, encodes a chimeric oncoprotein with transformation activity in multiple cell lineages [4]. In breast, salivary gland (secretory carcinomas), prostatic acinar adenocarcinoma, and ganglioglioma, Ntrk3 gene fusions have been identified as drivers or rare molecular events [1,2,3,5]. In upper tract urothelial carcinomas, higher Ntrk3 expression is correlated with worse survival outcomes, and it may interact with the PI3K-AKT-mTOR signaling pathway to promote cancer [6]. In Spitz tumours, Ntrk3 fusions expand the range of oncogenic kinase fusions in melanocytic neoplasms [7].
In conclusion, Ntrk3 is crucial in multiple biological processes and is significantly involved in various disease conditions, especially cancer. The discovery of Ntrk3 gene fusions in different cancers highlights its importance as a potential therapeutic target. Understanding Ntrk3's role through gene-based research models helps in developing more targeted treatment strategies for these cancers.
References：
1. Whaley, Rumeal D, Tekin, Burak, McCarthy, Michael R, Cheville, John C, Gupta, Sounak. 2024. NTRK3-Rearranged Prostatic Acinar Adenocarcinoma: Report of a Patient and Review of the Literature. In International journal of surgical pathology, 33, 204-208. doi:10.1177/10668969241253197. https://pubmed.ncbi.nlm.nih.gov/38772598/
2. Mortensen, Lindsey, Ordulu, Zehra, Dagogo-Jack, Ibiayi, Bardia, Aditya, Spring, Laura M. 2021. Locally Recurrent Secretory Carcinoma of the Breast with NTRK3 Gene Fusion. In The oncologist, 26, 818-824. doi:10.1002/onco.13880. https://pubmed.ncbi.nlm.nih.gov/34176200/
3. Rubino, Sebastian, Lynes, John, McBride, Paul, Macaulay, Robert, Vogelbaum, Michael A. 2022. NTRK3 gene fusion in an adult ganglioglioma: illustrative case. In Journal of neurosurgery. Case lessons, 3, . doi:10.3171/CASE21645. https://pubmed.ncbi.nlm.nih.gov/36130567/
4. Lannon, Chris L, Sorensen, Poul H B. . ETV6-NTRK3: a chimeric protein tyrosine kinase with transformation activity in multiple cell lineages. In Seminars in cancer biology, 15, 215-23. doi:. https://pubmed.ncbi.nlm.nih.gov/15826836/
5. Cardoni, Antonello, De Vito, Rita, Milano, Giuseppe Maria, De Pasquale, Maria Debora, Alaggio, Rita. 2022. A Pediatric Case of High-Grade Secretory Carcinoma of the Maxillary Sinus With ETV6::NTRK3 Gene Fusion, Therapeutic Implications, and Review of the Literature. In Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, 26, 59-64. doi:10.1177/10935266221138706. https://pubmed.ncbi.nlm.nih.gov/36448441/
6. Lim, Lee-Moay, Lee, Yi-Chen, Lin, Ting-Wei, Kuo, Hung-Tien, Huang, A-Mei. 2024. NTRK3 exhibits a pro-oncogenic function in upper tract urothelial carcinomas. In The Kaohsiung journal of medical sciences, 40, 445-455. doi:10.1002/kjm2.12824. https://pubmed.ncbi.nlm.nih.gov/38593276/
7. Yeh, Iwei, Tee, Meng Kian, Botton, Thomas, LeBoit, Philip E, Bastian, Boris C. . NTRK3 kinase fusions in Spitz tumours. In The Journal of pathology, 240, 282-290. doi:10.1002/path.4775. https://pubmed.ncbi.nlm.nih.gov/27477320/
8. Le Ciclé, Charles, Pacini, Vincent, Rama, Nicolas, Cohen-Tannoudji, Joëlle, L'hôte, David. 2023. The Neurod1/4-Ntrk3-Src pathway regulates gonadotrope cell adhesion and motility. In Cell death discovery, 9, 327. doi:10.1038/s41420-023-01615-7. https://pubmed.ncbi.nlm.nih.gov/37658038/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
