C57BL/6JCya-Ognem1flox/Cya
Common Name:
Ogn-flox
Product ID:
S-CKO-04073
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Ogn-flox
Strain ID
CKOCMP-18295-Ogn-B6J-VA
Gene Name
Product ID
S-CKO-04073
Gene Alias
3110079A16Rik; OG; OIF; SLRR3A; mimecan; mimican
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
13
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ognem1flox/Cya mice (Catalog S-CKO-04073) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000021822
NCBI RefSeq
NM_008760
Target Region
Exon 3
Size of Effective Region
~0.6 kb
Detailed Document
Overview of Gene Research
Ogn, previously known as mimecan, belongs to the small leucine-rich proteoglycans family. It plays pivotal functions in tissue formation, damage response, and is involved in various biological processes such as cell proliferation, apoptosis, and differentiation. It is also associated with multiple signaling pathways including the TGF-β/Smad, PI3K/Akt/mTOR, and OGN-Hh pathways [1,2,3,4].
In the context of diseases, Ogn shows diverse roles. In pancreatic cancer, its up-regulation promotes tumorigenesis by targeting ID4 [1]. In lung fibrosis, Ogn up-regulation in lung myofibroblasts is involved in the pathogenesis, and its knockdown attenuates fibrosis by inhibiting integrin αv-mediated TGF-β/Smad pathway activation [2]. In breast cancer, Ogn functions as a tumor suppressor, inhibiting cell proliferation and invasiveness via the PI3K/Akt/mTOR pathway [4]. In the study of tooth root development, Ogn-/-mice showed accelerated root length growth rate and thicker root hard tissues, likely due to Hh pathway activation and increased cell proliferation and differentiation [3].
In conclusion, Ogn is a multifunctional gene involved in tissue development and disease processes. The use of Ogn-/-mouse models has provided valuable insights into its role in tooth root development. In disease areas, it has been shown to have both tumor-promoting and tumor-suppressing roles, depending on the cancer type, and is also implicated in fibrotic diseases, highlighting its potential as a biomarker and therapeutic target.
References:
1. Qin, Wei, Zhang, Jing, Rong, Ruixue, Wang, Huiyun, Zhang, Yuntao. 2022. Osteoglycin (OGN) promotes tumorigenesis of pancreatic cancer cell via targeting ID4. In Tissue & cell, 78, 101867. doi:10.1016/j.tice.2022.101867. https://pubmed.ncbi.nlm.nih.gov/35908351/
2. Huang, Shaojie, Lin, Yingying, Deng, Qiwen, Wang, Zhongxing, Lai, Xiaofan. 2024. Suppression of OGN in lung myofibroblasts attenuates pulmonary fibrosis by inhibiting integrin αv-mediated TGF-β/Smad pathway activation. In Matrix biology : journal of the International Society for Matrix Biology, 132, 87-97. doi:10.1016/j.matbio.2024.07.001. https://pubmed.ncbi.nlm.nih.gov/39019241/
3. Lin, X, Li, Q, Hu, L, Wang, S, Wu, X. 2022. Apical Papilla Regulates Dental Follicle Fate via the OGN-Hh Pathway. In Journal of dental research, 102, 431-439. doi:10.1177/00220345221138517. https://pubmed.ncbi.nlm.nih.gov/36515316/
4. Xu, Tao, Zhang, Rui, Dong, Menglu, Zhan, Chenao, Li, Xingrui. 2019. Osteoglycin (OGN) Inhibits Cell Proliferation and Invasiveness in Breast Cancer via PI3K/Akt/mTOR Signaling Pathway. In OncoTargets and therapy, 12, 10639-10650. doi:10.2147/OTT.S222967. https://pubmed.ncbi.nlm.nih.gov/31824171/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen