C57BL/6JCya-Oxtrem1flox/Cya
Common Name:
Oxtr-flox
Product ID:
S-CKO-04138
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Oxtr-flox
Strain ID
CKOCMP-18430-Oxtr-B6J-VA
Gene Name
Product ID
S-CKO-04138
Gene Alias
OTR
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
6
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Oxtrem1flox/Cya mice (Catalog S-CKO-04138) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000053306
NCBI RefSeq
NM_001081147
Target Region
Exon 1
Size of Effective Region
~1.3 kb
Detailed Document
Overview of Gene Research
Oxtr, encoding the oxytocin receptor, is responsible for signal transduction upon binding its ligand, oxytocin. This signaling is mainly involved in controlling maternal behavior and also plays a role in nervous system development. The OXTR, a 7-transmembrane G protein-coupled receptor, activates signaling cascades like MAPK, PKC, PLC, or CaMK pathways, converging on transcription factors [1].
Oxtr has been associated with various diseases. Polymorphisms in the Oxtr gene are linked to social, emotional, and behavioral functioning in children and adolescents, such as in autism spectrum disorder, conduct disorder, depression, and anxiety [2]. In oral squamous cell carcinoma, OXTRHigh stroma fibroblasts contribute to local-regional metastasis via ERK5 signaling [3].
In conclusion, Oxtr is crucial for regulating maternal behavior and nervous system development, and its dysfunctions are associated with multiple diseases. Studies on Oxtr-related polymorphisms and its role in diseases like autism, depression, and cancer contribute to understanding the molecular mechanisms underlying these conditions, potentially paving the way for new therapeutic strategies.
References：
1. Jurek, Benjamin, Neumann, Inga D. . The Oxytocin Receptor: From Intracellular Signaling to Behavior. In Physiological reviews, 98, 1805-1908. doi:10.1152/physrev.00031.2017. https://pubmed.ncbi.nlm.nih.gov/29897293/
2. Kohlhoff, Jane, Cibralic, Sara, Hawes, David J, Eapen, Valsamma. 2022. Oxytocin receptor gene (OXTR) polymorphisms and social, emotional and behavioral functioning in children and adolescents: A systematic narrative review. In Neuroscience and biobehavioral reviews, 135, 104573. doi:10.1016/j.neubiorev.2022.104573. https://pubmed.ncbi.nlm.nih.gov/35149102/
3. Ding, Liang, Fu, Yong, Zhu, Nisha, Hu, Qingang, Ni, Yanhong. 2022. OXTRHigh stroma fibroblasts control the invasion pattern of oral squamous cell carcinoma via ERK5 signaling. In Nature communications, 13, 5124. doi:10.1038/s41467-022-32787-y. https://pubmed.ncbi.nlm.nih.gov/36045118/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen