Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Igbp1em1flox/Cya
Common Name:
Igbp1-flox
Product ID:
S-CKO-04177
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Igbp1-flox
Strain ID
CKOCMP-18518-Igbp1-B6J-VA
Gene Name
Igbp1
Product ID
S-CKO-04177
Gene Alias
Pc52; Tap42; p52
Background
C57BL/6JCya
NCBI ID
18518
Modification
Conditional knockout
Chromosome
X
Phenotype
MGI:1346500
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Igbp1em1flox/Cya mice (Catalog S-CKO-04177) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000033570
NCBI RefSeq
NM_008784
Target Region
Exon 3
Size of Effective Region
~1.8 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Immunoglobulin binding protein 1 (IGBP1), an important signal transduction regulator, is involved in multiple biological functions. It is a regulatory subunit of protein phosphatase 2A (Pp2a), sustaining mTOR signaling, and is associated with pathways like the PI3K/AKT pathway [1,2,4]. IGBP1 has been linked to cell differentiation, proliferation, apoptosis, and tolerance, especially of B cells [3].

IGBP1 shows potential as a biomarker and is associated with several diseases. In esophageal squamous cell carcinoma (ESCC), high IGBP1 expression correlates with poor prognosis and may act as a tumor promoter [1]. In lupus nephritis (LN), serum IGBP1 levels are high, positively correlated with the pathologic activity index, and can serve as a valid biomarker for detecting active nephritis [3]. Urinary IGBP1 may also be a novel biomarker reflecting the clinical and histological activities in LN [6]. In lung adenocarcinoma, miR-3941 can target IGBP1, and its suppression plays a role in early-stage disease progression [5].

In conclusion, IGBP1 is a key signal transduction regulator involved in multiple biological functions. Its role as a biomarker in diseases like ESCC, LN, and lung adenocarcinoma has been demonstrated through various studies. Understanding IGBP1's functions provides insights into disease mechanisms and potential therapeutic targets in these disease areas.

References:
1. Jiang, Sicong, Li, Daojing, Liang, Zibin, Pei, XiaoFeng, Tang, Jianjun. 2019. High expression of IGBP1 correlates with poor prognosis in esophageal squamous cell carcinoma. In The International journal of biological markers, 35, 33-40. doi:10.1177/1724600819896374. https://pubmed.ncbi.nlm.nih.gov/31875416/
2. Nadel, Guy, Yao, Zhong, Wainstein, Ehud, Horwitz, Benjamin A, Seger, Rony. 2022. GqPCR-stimulated dephosphorylation of AKT is induced by an IGBP1-mediated PP2A switch. In Cell communication and signaling : CCS, 20, 5. doi:10.1186/s12964-021-00805-z. https://pubmed.ncbi.nlm.nih.gov/34998390/
3. Ebaid, Amany M, Ezzeldin, Nillie, Abdelhady, Enas I, Mohammed, Heba A, Abdallah, Alshimaa L. 2022. Validity of immunoglobulin-binding protein 1 as a biomarker for lupus nephritis. In Lupus, 32, 101-110. doi:10.1177/09612033221141278. https://pubmed.ncbi.nlm.nih.gov/36418233/
4. Grech, Godfrey, Blázquez-Domingo, Montserrat, Kolbus, Andrea, Beug, Hartmut, von Lindern, Marieke. 2008. Igbp1 is part of a positive feedback loop in stem cell factor-dependent, selective mRNA translation initiation inhibiting erythroid differentiation. In Blood, 112, 2750-60. doi:10.1182/blood-2008-01-133140. https://pubmed.ncbi.nlm.nih.gov/18625885/
5. Sato, Taiki, Shiba-Ishii, Aya, Kim, Yunjung, Iijima, Tatsuo, Noguchi, Masayuki. . miR-3941: A novel microRNA that controls IGBP1 expression and is associated with malignant progression of lung adenocarcinoma. In Cancer science, 108, 536-542. doi:10.1111/cas.13148. https://pubmed.ncbi.nlm.nih.gov/28012229/
6. Lee, Eun-Ju, Kwon, Oh Chan, Ghang, Byeongzu, Yoo, Bin, Kim, Yong-Gil. 2019. Immunoglobulin Binding Protein 1 as a Potential Urine Biomarker in Patients with Lupus Nephritis. In International journal of molecular sciences, 20, . doi:10.3390/ijms20102606. https://pubmed.ncbi.nlm.nih.gov/31137925/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest