C57BL/6JCya-Igbp1em1flox/Cya
Common Name
Igbp1-flox
Product ID
S-CKO-04177
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-18518-Igbp1-B6J-VA
When using this mouse strain in a publication, please cite “Igbp1-flox Mouse (Catalog S-CKO-04177) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Igbp1-flox
Strain ID
CKOCMP-18518-Igbp1-B6J-VA
Gene Name
Product ID
S-CKO-04177
Gene Alias
p52, Pc52, Tap42
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr X
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000033570
NCBI RefSeq
NM_008784
Target Region
Exon 3
Size of Effective Region
~1.8 kb
Overview of Gene Research
Immunoglobulin binding protein 1 (IGBP1), an important signal transduction regulator, is involved in multiple biological functions. It is a regulatory subunit of protein phosphatase 2A (Pp2a), sustaining mTOR signaling, and is associated with pathways like the PI3K/AKT pathway [1,2,4]. IGBP1 has been linked to cell differentiation, proliferation, apoptosis, and tolerance, especially of B cells [3].
IGBP1 shows potential as a biomarker and is associated with several diseases. In esophageal squamous cell carcinoma (ESCC), high IGBP1 expression correlates with poor prognosis and may act as a tumor promoter [1]. In lupus nephritis (LN), serum IGBP1 levels are high, positively correlated with the pathologic activity index, and can serve as a valid biomarker for detecting active nephritis [3]. Urinary IGBP1 may also be a novel biomarker reflecting the clinical and histological activities in LN [6]. In lung adenocarcinoma, miR-3941 can target IGBP1, and its suppression plays a role in early-stage disease progression [5].
In conclusion, IGBP1 is a key signal transduction regulator involved in multiple biological functions. Its role as a biomarker in diseases like ESCC, LN, and lung adenocarcinoma has been demonstrated through various studies. Understanding IGBP1's functions provides insights into disease mechanisms and potential therapeutic targets in these disease areas.
References：
1. Jiang, Sicong, Li, Daojing, Liang, Zibin, Pei, XiaoFeng, Tang, Jianjun. 2019. High expression of IGBP1 correlates with poor prognosis in esophageal squamous cell carcinoma. In The International journal of biological markers, 35, 33-40. doi:10.1177/1724600819896374. https://pubmed.ncbi.nlm.nih.gov/31875416/
2. Nadel, Guy, Yao, Zhong, Wainstein, Ehud, Horwitz, Benjamin A, Seger, Rony. 2022. GqPCR-stimulated dephosphorylation of AKT is induced by an IGBP1-mediated PP2A switch. In Cell communication and signaling : CCS, 20, 5. doi:10.1186/s12964-021-00805-z. https://pubmed.ncbi.nlm.nih.gov/34998390/
3. Ebaid, Amany M, Ezzeldin, Nillie, Abdelhady, Enas I, Mohammed, Heba A, Abdallah, Alshimaa L. 2022. Validity of immunoglobulin-binding protein 1 as a biomarker for lupus nephritis. In Lupus, 32, 101-110. doi:10.1177/09612033221141278. https://pubmed.ncbi.nlm.nih.gov/36418233/
4. Grech, Godfrey, Blázquez-Domingo, Montserrat, Kolbus, Andrea, Beug, Hartmut, von Lindern, Marieke. 2008. Igbp1 is part of a positive feedback loop in stem cell factor-dependent, selective mRNA translation initiation inhibiting erythroid differentiation. In Blood, 112, 2750-60. doi:10.1182/blood-2008-01-133140. https://pubmed.ncbi.nlm.nih.gov/18625885/
5. Sato, Taiki, Shiba-Ishii, Aya, Kim, Yunjung, Iijima, Tatsuo, Noguchi, Masayuki. . miR-3941: A novel microRNA that controls IGBP1 expression and is associated with malignant progression of lung adenocarcinoma. In Cancer science, 108, 536-542. doi:10.1111/cas.13148. https://pubmed.ncbi.nlm.nih.gov/28012229/
6. Lee, Eun-Ju, Kwon, Oh Chan, Ghang, Byeongzu, Yoo, Bin, Kim, Yong-Gil. 2019. Immunoglobulin Binding Protein 1 as a Potential Urine Biomarker in Patients with Lupus Nephritis. In International journal of molecular sciences, 20, . doi:10.3390/ijms20102606. https://pubmed.ncbi.nlm.nih.gov/31137925/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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