C57BL/6JCya-Serpine1em1flox/Cya
Common Name:
Serpine1-flox
Product ID:
S-CKO-04327
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Serpine1-flox
Strain ID
CKOCMP-18787-Serpine1-B6J-VA
Gene Name
Product ID
S-CKO-04327
Gene Alias
PAI-1; PAI1; Planh1
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
5
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Serpine1em1flox/Cya mice (Catalog S-CKO-04327) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000041388
NCBI RefSeq
NM_008871
Target Region
Exon 4~5
Size of Effective Region
~2.0 kb
Detailed Document
Overview of Gene Research
Serpine1, also known as Plasminogen Activator Inhibitor (PAI-1), is a key member of the serine proteinase inhibitor E superfamily. It plays a crucial role in the fibrinolytic system and is involved in various biological processes. It has been associated with multiple signaling pathways such as the NF-κB signaling pathway, which is relevant in many disease-related processes [1,2].
In colorectal cancer, therapy-induced senescent tumor cells release extracellular vesicles enriched in SERPINE1, which promote cancer progression. SERPINE1 binds to p65, promoting its nuclear translocation and activating the NF-κB signaling pathway [1]. In gastric cancer, SERPINE1 is up-regulated, related to poor prognosis, and may regulate cuproptosis and the immune microenvironment. It is negatively correlated with cuproptosis-related genes FDX1, LIAS, LIPT1, and PDHA1, and positively correlated with APOE. It may also promote an inhibitory immune microenvironment [3].
In conclusion, Serpine1 is an important gene involved in the fibrinolytic system and is associated with multiple diseases, especially cancers. Studies in cancer models have revealed its role in promoting tumor progression, regulating the immune microenvironment, and being a potential prognostic biomarker and therapeutic target [1,3].
References:
1. Zhang, Dan, Zhang, Jian-Wei, Xu, Hui, Peng, Jin, Zhou, Fu-Xiang. 2024. Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF-κB p65 nuclear translocation. In Molecular cancer, 23, 70. doi:10.1186/s12943-024-01985-1. https://pubmed.ncbi.nlm.nih.gov/38576002/
2. Chen, Teng-Yu, Zhou, Min, Lin, Man-Qing, Li, Dan, Ruan, Yan. 2021. Research Progress on the SERPINE1 Protein and Chronic Inflammatory Diseases of the Upper Respiratory Tract: A Literature Review. In International archives of allergy and immunology, 182, 1097-1102. doi:10.1159/000516195. https://pubmed.ncbi.nlm.nih.gov/33946071/
3. Feng, Leiran, Li, Guixin, Li, Dongbin, Duan, Guoqiang, Liu, Jin. 2023. Cuproptosis-related gene SERPINE1 is a prognostic biomarker and correlated with immune infiltrates in gastric cancer. In Journal of cancer research and clinical oncology, 149, 10851-10865. doi:10.1007/s00432-023-04900-1. https://pubmed.ncbi.nlm.nih.gov/37318594/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen