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C57BL/6JCya-Plcb1em1flox/Cya
Common Name:
Plcb1-flox
Product ID:
S-CKO-04333
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Plcb1-flox
Strain ID
CKOCMP-18795-Plcb1-B6J-VA
Gene Name
Plcb1
Product ID
S-CKO-04333
Gene Alias
3110043I21Rik; Plcb; mKIAA0581
Background
C57BL/6JCya
NCBI ID
18795
Modification
Conditional knockout
Chromosome
2
Phenotype
MGI:97613
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Plcb1em1flox/Cya mice (Catalog S-CKO-04333) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000131552
NCBI RefSeq
NM_019677
Target Region
Exon 6~7
Size of Effective Region
~2.0 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Plcb1, short for phospholipase C beta 1, is a member of the phospholipase family involved in phospholipid hydrolysis. It is associated with multiple pathways such as the PI3K/AKT signaling pathway and plays a role in regulating the abundance of PI(4,5)P2 in the plasma membrane. Genetic models, like gene-knockout mouse models, have been crucial in studying its functions in various biological processes and disease conditions [1,2].

In cholangiocarcinoma, Plcb1 promotes tumor development and growth, activates the PI3K/AKT signaling axis to induce epithelial-to-mesenchymal transition (EMT), and confers resistance to gemcitabine combined with cisplatin treatment [1]. In gastric cancer, it enhances cell migration and invasion by regulating actin cytoskeletal remodeling and EMT [2]. In gliomas, increased oxygen stimulation affects chemoresistance and phenotype shifting through regulating Plcb1, which is involved in the proteasomal degradation of β-catenin and activation of the Wnt signaling pathway [3]. Heterozygous deletion of Plcb1 in mice reduces cue-induced reinstatement of cocaine-seeking behavior, suggesting its potential as a therapeutic target for cocaine addiction [4].

In conclusion, Plcb1 is essential in processes like tumor cell progression and addiction-related behaviors. Studies using KO/CKO mouse models have revealed its role in cholangiocarcinoma, gastric cancer, gliomas, and cocaine addiction, providing insights into potential therapeutic strategies for these disease areas.

References:
1. Liang, Shuhang, Guo, Hongrui, Ma, Kun, Wang, Jiabei, Liu, Lianxin. 2021. A PLCB1-PI3K-AKT Signaling Axis Activates EMT to Promote Cholangiocarcinoma Progression. In Cancer research, 81, 5889-5903. doi:10.1158/0008-5472.CAN-21-1538. https://pubmed.ncbi.nlm.nih.gov/34580062/
2. Wang, Yulin, Tu, Zhiyue, Zhao, Wei, Wang, Yibin, Bi, Yinglu. 2023. PLCB1 Enhances Cell Migration and Invasion in Gastric Cancer Via Regulating Actin Cytoskeletal Remodeling and Epithelial-Mesenchymal Transition. In Biochemical genetics, 61, 2618-2632. doi:10.1007/s10528-023-10396-8. https://pubmed.ncbi.nlm.nih.gov/37208557/
3. Ma, Kang, Wang, Shi, Ma, Yingjie, Li, Fei, Chen, Tunan. 2024. Increased oxygen stimulation promotes chemoresistance and phenotype shifting through PLCB1 in gliomas. In Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, 76, 101113. doi:10.1016/j.drup.2024.101113. https://pubmed.ncbi.nlm.nih.gov/39053384/
4. Cabana-Domínguez, Judit, Martín-García, Elena, Gallego-Roman, Ana, Fernàndez-Castillo, Noèlia, Cormand, Bru. 2021. Reduced cue-induced reinstatement of cocaine-seeking behavior in Plcb1 +/- mice. In Translational psychiatry, 11, 521. doi:10.1038/s41398-021-01396-6. https://pubmed.ncbi.nlm.nih.gov/34635637/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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