C57BL/6JCya-Lgals3bpem1flox/Cya
Common Name:
Lgals3bp-flox
Product ID:
S-CKO-04406
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Lgals3bp-flox
Strain ID
CKOCMP-19039-Lgals3bp-B6J-VA
Gene Name
Product ID
S-CKO-04406
Gene Alias
90K; CyCAP; MAC-2BP; Ppicap; Tango10b
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
11
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Lgals3bpem1flox/Cya mice (Catalog S-CKO-04406) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000043722
NCBI RefSeq
NM_011150.3
Target Region
Exon 3~5
Size of Effective Region
~2.9 kb
Detailed Document
Overview of Gene Research
LGALS3BP, also known as galectin 3-binding protein or 90K, is a multifunctional glycoprotein involved in various biological processes, including immunity and cancer. It is associated with several signaling pathways, such as the TGF-β1 signaling pathway, which is crucial in hepatic fibrosis and carcinogenesis [1].
In the context of hepatic diseases, LGALS3BP-knockout mice studies revealed that LGALS3BP deletion in hepatocytes downregulated TGF-β1 signaling and CCl4-induced fibrosis. LGALS3BP directly binds to and assembles integrin αV, releasing active TGF-β1, which activates JunB and promotes a TGF-β1 positive feedback loop. Thus, LGALS3BP depletion hindered hepatocarcinogenesis by limiting the availability of fibrogenic TGF-β1 [1].
In colon inflammation and tumorigenesis, Lgals3bp-/-mice were highly susceptible to colitis and colon tumorigenesis. Lgals3bp suppressed NF-κB through the downregulation of TAK1 in colon epithelial cells, indicating its role in suppressing colitis and colon tumorigenesis [2].
In conclusion, LGALS3BP plays essential roles in multiple biological processes and diseases. Its functions in hepatic fibrosis, hepatocarcinogenesis, colon inflammation, and tumorigenesis have been well-demonstrated through gene-knockout mouse models. These studies of LGALS3BP contribute to a better understanding of the disease mechanisms and may provide potential therapeutic targets for related diseases.
References:
1. Kim, Dae-Hwan, Sung, Minjeong, Park, Myong-Suk, Cho, Sang-Hee, Chung, Ik-Joo. 2024. Galectin 3-binding protein (LGALS3BP) depletion attenuates hepatic fibrosis by reducing transforming growth factor-β1 (TGF-β1) availability and inhibits hepatocarcinogenesis. In Cancer communications (London, England), 44, 1106-1129. doi:10.1002/cac2.12600. https://pubmed.ncbi.nlm.nih.gov/39073023/
2. Cho, Sang-Hee, Shim, Hyun-Jeong, Park, Mi-Ra, Sun, Eun-Gene, Chung, Ik-Joo. 2021. Lgals3bp suppresses colon inflammation and tumorigenesis through the downregulation of TAK1-NF-κB signaling. In Cell death discovery, 7, 65. doi:10.1038/s41420-021-00447-7. https://pubmed.ncbi.nlm.nih.gov/33824294/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen