Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Prkab1em1flox/Cya
Common Name:
Prkab1-flox
Product ID:
S-CKO-04435
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Prkab1-flox
Strain ID
CKOCMP-19079-Prkab1-B6J-VA
Gene Name
Prkab1
Product ID
S-CKO-04435
Gene Alias
1300015D22Rik; E430008F22
Background
C57BL/6JCya
NCBI ID
19079
Modification
Conditional knockout
Chromosome
5
Phenotype
MGI:1336167
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Prkab1em1flox/Cya mice (Catalog S-CKO-04435) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000031486
NCBI RefSeq
NM_031869
Target Region
Exon 2
Size of Effective Region
~1.5 kb
Detailed Document
Click here to download >>
Overview of Gene Research
PRKAB1, encoding the β1 regulatory subunit of AMP-activated protein kinase (AMPK), is crucial in regulating the metabolism of carbohydrate, lipid, and protein, and is considered a key regulator of cellular energy homeostasis [2]. AMPK is an evolutionarily conserved sensor of cellular and systemic energy balance, and PRKAB1 has been shown to be highly involved in glycogen metabolism [7,8].

In a multi-omics study on Crohn's disease, PRKAB1 was identified as one of the genes involved in gene-microbiota interactions. The association between PRKAB1-Escherichia coli in the validation cohort was consistent with eQTL-mbQTL colocalization, suggesting its role in the disease mechanism [1]. In goats, four novel single nucleotide polymorphisms (SNPs) of PRKAB1 were found, with some SNPs showing significant associations with growth traits in Xuhuai goats [2]. In a Mendelian randomization study on glucose-lowering drug targets and gastrointestinal cancer, weak evidence indicated connections of PRKAB1 with anal carcinoma, cardia cancer, ICC, and rectum cancer [3]. A study on non-alcoholic steatohepatitis (NASH) showed that a compound, buddleoside, bound to the PRKAB1 subunit and activated AMPK, alleviating NASH symptoms [4]. Also, in non-alcoholic fatty liver disease (NAFLD), miR-802 was found to inhibit hepatic AMPK expression by binding to the 3' untranslated region of Prkab1, and schisanhenol improved NAFLD by targeting the miR-802/AMPK pathway related to PRKAB1 [5]. A Mendelian randomization study on lung cancer showed that the PRKAB1 gene was associated with a lower risk of developing lung adenocarcinoma [6].

In conclusion, PRKAB1 is essential for regulating cellular energy homeostasis and metabolism. Studies in various disease models such as Crohn's disease, NASH, NAFLD, and in relation to growth traits in goats, and cancer risks, have revealed its significance in disease mechanisms and biological processes. These model-based studies contribute to understanding the role of PRKAB1 in different physiological and pathological conditions.

References:
1. Xu, Shu, Li, Xiaozhi, Zhang, Shenghong, Feng, Rui, Chen, Minhu. 2023. Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn's disease: a multi-omics Mendelian randomization study. In BMC medicine, 21, 179. doi:10.1186/s12916-023-02878-8. https://pubmed.ncbi.nlm.nih.gov/37170220/
2. Zhou, Shengliang, Shi, Xiuying, Song, Chengchuang, Chen, Hong, Fang, Xingtang. 2021. SNP discovery of PRKAB1 gene and their associations with growth traits in goats. In Animal biotechnology, 33, 1613-1619. doi:10.1080/10495398.2021.1920426. https://pubmed.ncbi.nlm.nih.gov/34106801/
3. Yang, Yi, Chen, Bo, Zheng, Chongming, Chen, Gang, Wang, Yi. 2024. Association of glucose-lowering drug target and risk of gastrointestinal cancer: a mendelian randomization study. In Cell & bioscience, 14, 36. doi:10.1186/s13578-024-01214-8. https://pubmed.ncbi.nlm.nih.gov/38504335/
4. Chen, Meng, Liu, Guowen, Fang, Zhiyuan, Du, Xiliang, Li, Xinwei. 2025. Buddleoside alleviates nonalcoholic steatohepatitis by targeting the AMPK-TFEB signaling pathway. In Autophagy, , 1-19. doi:10.1080/15548627.2025.2466145. https://pubmed.ncbi.nlm.nih.gov/39936600/
5. Li, Bin, Xiao, Qi, Zhao, Hongmei, Sun, Haitao, Liu, Haitao. 2024. Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism. In Acta pharmaceutica Sinica. B, 14, 3949-3963. doi:10.1016/j.apsb.2024.05.014. https://pubmed.ncbi.nlm.nih.gov/39309511/
6. Sun, Wen, Zhang, Xiaoyu, Li, Ning, Ji, Jianguang, Zheng, Deqiang. 2024. Genetic association of glycemic traits and antihyperglycemic agent target genes with the risk of lung cancer: A Mendelian randomization study. In Diabetes & metabolic syndrome, 18, 103048. doi:10.1016/j.dsx.2024.103048. https://pubmed.ncbi.nlm.nih.gov/38850595/
7. Zhang, Qin, Chen, Hong, Zhao, Sheng, Zhang, Liangzhi, Wang, Xueming. 2009. Polymorphisms in the promoter region of bovine PRKAB1 gene. In Molecular biology reports, 37, 435-40. doi:10.1007/s11033-009-9612-5. https://pubmed.ncbi.nlm.nih.gov/19609721/
8. Zhang, Qin, Chen, Hong, Zhao, Sheng, Li, Fei, Wang, Xueming. 2009. Single nucleotide polymorphisms and haplotypic diversity in the bovine PRKAB1 gene. In Molecular biotechnology, 43, 193-9. doi:10.1007/s12033-009-9194-4. https://pubmed.ncbi.nlm.nih.gov/19578998/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest