C57BL/6NCya-Procem1flox/Cya
Common Name:
Proc-flox
Product ID:
S-CKO-04458
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Proc-flox
Strain ID
CKOCMP-19123-Proc-B6N-VA
Gene Name
Product ID
S-CKO-04458
Gene Alias
PC
Background
C57BL/6NCya
NCBI ID
Modification
Conditional knockout
Chromosome
18
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Procem1flox/Cya mice (Catalog S-CKO-04458) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000171765
NCBI RefSeq
NM_001042767
Target Region
Exon 3
Size of Effective Region
~1.4 kb
Detailed Document
Overview of Gene Research
PROC, also known as Protein C, Inactivator Of Coagulation Factors Va And VIIIa, is a gene encoding protein C, an anticoagulation agent. Protein C deficiency, resulting from pathogenic variants of the PROC gene, can lead to vascular thrombosis disease, highlighting its importance in the anticoagulation pathway [1,2].
In a Chinese family, a novel mutation (c.237 + 5G > A) in intron 3 of the PROC gene was identified in a patient with pulmonary embolism caused by protein C deficiency [1]. In another study, a rare pathogenic variant (p.Ala178Pro) was found in four venous thrombosis (VTE) subjects, with in-vitro study showing reduced PROC antigen secretion and lower PROC activity levels in carriers [2]. Additionally, analysis of PROC SNPs in a thrombophilia family showed an association between certain SNPs and deep venous thrombosis (DVT) [3]. In the pediatric population, three SNPs at the PROC promoter region were associated with lower protein C activity but not an increased risk of thromboembolism [4].
In conclusion, the PROC gene is crucial for maintaining normal anticoagulation function. Genetic studies on PROC, such as identifying pathogenic variants and SNPs, have provided insights into its role in thrombosis-related diseases. Understanding the function of PROC through these genetic models helps in elucidating the mechanisms of vascular thrombosis diseases and may potentially guide the development of preventive and treatment strategies.
References:
1. Zhang, Zhaorui, Yang, Zhen, Chen, Mei, Li, Yuzhu. . Compound heterozygous protein C deficiency with pulmonary embolism caused by a novel PROC gene mutation: Case report and literature review. In Medicine, 101, e31221. doi:10.1097/MD.0000000000031221. https://pubmed.ncbi.nlm.nih.gov/36281079/
2. Yue, Yongjian, Liu, Shengguo, Han, Xuemei, Zou, Chang, Fu, Yingyun. 2019. Pathogenic variants of PROC gene caused type I activity deficiency in a familial Chinese venous thrombosis. In Journal of cellular and molecular medicine, 23, 7099-7104. doi:10.1111/jcmm.14563. https://pubmed.ncbi.nlm.nih.gov/31338992/
3. Wu, Dawen, Zhong, Zhanghua, Chen, Yunfei, Zhao, Jianming, Deng, Chaosheng. 2019. Analysis of PROC and PROS1 single nucleotide polymorphisms in a thrombophilia family. In The clinical respiratory journal, 13, 530-537. doi:10.1111/crj.13055. https://pubmed.ncbi.nlm.nih.gov/31295762/
4. Udomkittivorakul, Natsumon, Sasanakul, Werasak, Eu-Ahsunthornwattana, Jakris, Songdej, Duantida, Sirachainan, Nongnuch. . PROC Promoter Single Nucleotide Polymorphisms Associated With Low Protein C Activity But Not Increased Risk of Thromboembolism in Pediatric Population. In Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 26, 1076029620935206. doi:10.1177/1076029620935206. https://pubmed.ncbi.nlm.nih.gov/32609543/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen