C57BL/6JCya-Stab1em1flox/Cya
Common Name
Stab1-flox
Product ID
S-CKO-04536
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-192187-Stab1-B6J-VA
Status
When using this mouse strain in a publication, please cite “Stab1-flox Mouse (Catalog S-CKO-04536) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Stab1-flox
Strain ID
CKOCMP-192187-Stab1-B6J-VA
Gene Name
Product ID
S-CKO-04536
Gene Alias
MS-1, FEEL-1, FELE-1, STAB-1, MFEEL-1, mKIAA0246
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 14 (Mouse)
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Transcript ID
ENSMUST00000036618
NCBI Transcript ID
NM_138672
Target Region
Exon 19~22
Size of Effective Region
~2.5 kb
Overview of Gene Research
Stab1, encoding the multifunctional scavenger receptor stabilin-1, is preferentially expressed by liver sinusoidal endothelial cells. It mediates the clearance of circulating plasma molecules, thus controlling distant organ homeostasis [1]. It has also been associated with the regulation of the IKK/NF-κB pathway [2].
In ApoE-KO mice interbred with Stab1-KO mice, spontaneous and Western diet-associated atherogenesis was significantly reduced, suggesting that targeting Stab1 can ameliorate atherosclerosis [1]. In acute myeloid leukemia (AML), STAB1 knockdown in human AML cell lines HEL and NB4 suppressed proliferation and promoted apoptosis through regulating the IKK/NF-κB pathway, and STAB1 silencing prolonged survival in xenograft mouse models [2]. In malignant mesothelioma, STAB1 was among the genes that could potentially be specific therapeutic targets as monocyte-derived macrophages expressing STAB1 play a role in tumor development [3]. In cytogenetically normal AML (CN-AML), high STAB1 expression was associated with poor outcomes, and STAB1 suppression inhibited cell growth in KG1a and NB4 leukemia cells [4].
In conclusion, Stab1 is crucial for plasma molecule clearance and organ homeostasis. Gene-knockout mouse models have revealed its role in diseases such as atherosclerosis, AML, and malignant mesothelioma. Targeting Stab1 may offer potential therapeutic strategies for these diseases.
References：
1. Manta, Calin-Petru, Leibing, Thomas, Friedrich, Mirco, Goerdt, Sergij, Géraud, Cyrill. 2022. Targeting of Scavenger Receptors Stabilin-1 and Stabilin-2 Ameliorates Atherosclerosis by a Plasma Proteome Switch Mediating Monocyte/Macrophage Suppression. In Circulation, 146, 1783-1799. doi:10.1161/CIRCULATIONAHA.121.058615. https://pubmed.ncbi.nlm.nih.gov/36325910/
2. Yin, Jiaxiu, Luo, Jing, Wang, Lan, Liu, Lanxiang, Liu, Lin. 2025. STAB1 Promotes Acute Myeloid Leukemia Progression by Activating the IKK/NF-κB Pathway and Increasing M2 Macrophage Polarization. In Cancer science, , . doi:10.1111/cas.70044. https://pubmed.ncbi.nlm.nih.gov/40083109/
3. Wu, Licun, Kohno, Mikihiro, Murakami, Junichi, Pugh, Trevor J, de Perrot, Marc. 2023. Defining and targeting tumor-associated macrophages in malignant mesothelioma. In Proceedings of the National Academy of Sciences of the United States of America, 120, e2210836120. doi:10.1073/pnas.2210836120. https://pubmed.ncbi.nlm.nih.gov/36821580/
4. Lin, Sheng-Yan, Hu, Fei-Fei, Miao, Ya-Ru, Chen, Zhichao, Guo, An-Yuan. 2019. Identification of STAB1 in Multiple Datasets as a Prognostic Factor for Cytogenetically Normal AML: Mechanism and Drug Indications. In Molecular therapy. Nucleic acids, 18, 476-484. doi:10.1016/j.omtn.2019.09.014. https://pubmed.ncbi.nlm.nih.gov/31670197/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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