C57BL/6JCya-Ptgfrem1flox/Cya
Common Name:
Ptgfr-flox
Product ID:
S-CKO-04550
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Ptgfr-flox
Strain ID
CKOCMP-19220-Ptgfr-B6J-VA
Gene Name
Product ID
S-CKO-04550
Gene Alias
PGF; fp
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
3
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ptgfrem1flox/Cya mice (Catalog S-CKO-04550) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000029670
NCBI RefSeq
NM_008966
Target Region
Exon 2
Size of Effective Region
~2.2 kb
Detailed Document
Overview of Gene Research
Ptgfr, the prostaglandin F2α receptor, is crucial for mediating the effects of prostaglandin F2α (PGF2α) in various biological processes. It is involved in pathways related to cell proliferation, tissue remodeling, and angiogenesis. PGF2α-Ptgfr signaling is of great biological importance in processes such as endometrial function, retinal angiogenesis, and fibrotic remodeling [1,2,3,4].
In a mouse model of oxygen-induced retinopathy, disruption of the Ptgfr in endothelial cells attenuated the retinopathy, indicating that Ptgfr promotes pathological retinal angiogenesis [3]. In a murine idiopathic pulmonary fibrosis (IPF) model (IER-SftpcI73T), crossing to a Ptgfr-null (FPr-/ -) line led to attenuated weight loss, gene dosage-dependent rescue of mortality, and reductions in multiple fibrotic endpoints, suggesting that PGF2α-Ptgfr signaling drives fibrotic remodeling in IPF [4].
In conclusion, Ptgfr plays essential roles in regulating processes like endometrial cell proliferation, endometrial breakdown, pathological retinal angiogenesis, and fibrotic remodeling. The use of Ptgfr-null mouse models in these studies has significantly enhanced our understanding of its functions in diseases such as retinopathy and IPF.
References：
1. Fu, Changqi, Mao, Wei, Gao, Ruifeng, Cao, Jinshan, Liu, Bo. 2020. Prostaglandin F2α-PTGFR signaling promotes proliferation of endometrial epithelial cells of cattle through cell cycle regulation. In Animal reproduction science, 213, 106276. doi:10.1016/j.anireprosci.2020.106276. https://pubmed.ncbi.nlm.nih.gov/31987327/
2. Zhou, Fang, Wang, Shufang, Lu, Wenhong, Zhuang, Taifeng, Xu, Xiangbo. 2024. The Essential Role of PGF2α/PTGFR in Molding Endometrial Breakdown and Vascular Dynamics, Regulated by HIF-1α in a Mouse Menstrual-like Model. In Reproductive sciences (Thousand Oaks, Calif.), 31, 2718-2730. doi:10.1007/s43032-024-01526-7. https://pubmed.ncbi.nlm.nih.gov/38637474/
3. Zhao, Yan, Lei, Yi, Ning, Huying, Yan, Hua, Yu, Ying. 2022. PGF2α facilitates pathological retinal angiogenesis by modulating endothelial FOS-driven ELR+ CXC chemokine expression. In EMBO molecular medicine, 15, e16373. doi:10.15252/emmm.202216373. https://pubmed.ncbi.nlm.nih.gov/36511116/
4. Rodriguez, Luis R, Tang, Soon Yew, Roque Barboza, Willy, FitzGerald, Garret A, Beers, Michael F. 2023. PGF2α signaling drives fibrotic remodeling and fibroblast population dynamics in mice. In JCI insight, 8, . doi:10.1172/jci.insight.172977. https://pubmed.ncbi.nlm.nih.gov/37934604/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen