C57BL/6JCya-Ptgs1em1flox/Cya
Common Name:
Ptgs1-flox
Product ID:
S-CKO-04559
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Ptgs1-flox
Strain ID
CKOCMP-19224-Ptgs1-B6J-VA
Gene Name
Product ID
S-CKO-04559
Gene Alias
COX1; Cox-1; Cox-3; PGHS-1; PHS 1; Pghs1
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
2
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ptgs1em1flox/Cya mice (Catalog S-CKO-04559) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000062069
NCBI RefSeq
NM_008969
Target Region
Exon 3~7
Size of Effective Region
~4.4 kb
Detailed Document
Overview of Gene Research
Ptgs1, also known as prostaglandin-endoperoxide synthase 1 or cyclooxygenase (COX) 1, is a key enzyme in the biosynthesis of prostaglandins from arachidonic acid. It participates in maintaining normal physiological functions in the body, such as protecting the gastrointestinal mucosa, regulating platelet aggregation, and influencing vascular tone. The gene is involved in multiple biological pathways, and its activity is crucial for the balance of inflammation, cell growth, and tissue repair [1].
In the context of disease, in prostate cancer, androgen deprivation-induced ZBTB46-PTGS1 signaling promotes neuroendocrine differentiation [2]. In chronic myeloid leukemia, the proto-oncogene EVI1 upregulates PTGS1, reducing the action of tyrosine kinase inhibitors [3]. In non-small cell lung cancer, dihydroartemisinin, a potential PTGS1 inhibitor, potentiates cisplatin-induced cell death [4]. For osteoporosis and benign breast tumors in Korean women, PTGS1 gene variants are associated with these phenotypes and are modulated by ovariectomy [5]. In Chinese patients with ischemic stroke treated with aspirin, PTGS1 rs10306114 polymorphisms are related to stroke recurrence [6]. In Chinese Han stroke patients with aspirin therapy, PTGS1 polymorphisms interact with smoking to affect functional outcomes [7].
In conclusion, Ptgs1 is essential for normal physiological functions and is intricately involved in various disease processes. Research on Ptgs1, including through genetic models, has provided insights into its role in diseases such as cancer, leukemia, stroke, and osteoporosis, offering potential therapeutic targets for these conditions.
References:
1. Bjarnason, Ingvar, Scarpignato, Carmelo, Holmgren, Erik, Rainsford, Kim D, Lanas, Angel. 2017. Mechanisms of Damage to the Gastrointestinal Tract From Nonsteroidal Anti-Inflammatory Drugs. In Gastroenterology, 154, 500-514. doi:10.1053/j.gastro.2017.10.049. https://pubmed.ncbi.nlm.nih.gov/29221664/
2. Chen, Wei-Yu, Zeng, Tao, Wen, Yu-Chng, Huang, Jiaoti, Liu, Yen-Nien. 2018. Androgen deprivation-induced ZBTB46-PTGS1 signaling promotes neuroendocrine differentiation of prostate cancer. In Cancer letters, 440-441, 35-46. doi:10.1016/j.canlet.2018.10.004. https://pubmed.ncbi.nlm.nih.gov/30312731/
3. Vinothkumar, Kittappa, Chanda, Sayantan, Singh, Vivek Kumar, Biswas, Ghanashyam, Chakraborty, Soumen. 2022. EVI1 upregulates PTGS1 (COX1) and decreases the action of tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia cells. In International journal of hematology, 117, 110-120. doi:10.1007/s12185-022-03465-y. https://pubmed.ncbi.nlm.nih.gov/36282419/
4. Ni, Lianli, Zhu, Xinping, Zhao, Qi, Cui, Ri, Zhu, Wangyu. 2024. Dihydroartemisinin, a potential PTGS1 inhibitor, potentiated cisplatin-induced cell death in non-small cell lung cancer through activating ROS-mediated multiple signaling pathways. In Neoplasia (New York, N.Y.), 51, 100991. doi:10.1016/j.neo.2024.100991. https://pubmed.ncbi.nlm.nih.gov/38507887/
5. Cho, Hye-Won, Jin, Hyun-Seok, Eom, Yong-Bin. 2021. MYLK and PTGS1 Genetic Variations Associated with Osteoporosis and Benign Breast Tumors in Korean Women. In Genes, 12, . doi:10.3390/genes12030378. https://pubmed.ncbi.nlm.nih.gov/33800915/
6. Zhang, Linlin, Meng, Zhongru, Wang, Hongxia, Miao, Yang. . Effect of PEAR1, PTGS1 gene polymorphisms on the recurrence of aspirin-treated patients with ischemic stroke in the Han population of China: A 4-year follow-up study. In Medicine, 103, e38031. doi:10.1097/MD.0000000000038031. https://pubmed.ncbi.nlm.nih.gov/38728491/
7. Cai, Huan, Cai, Biyang, Sun, Lingli, Zhang, Zhizhong, Liu, Xinfeng. 2017. Association between PTGS1 polymorphisms and functional outcomes in Chinese patients with stroke during aspirin therapy: Interaction with smoking. In Journal of the neurological sciences, 376, 211-215. doi:10.1016/j.jns.2017.03.014. https://pubmed.ncbi.nlm.nih.gov/28431615/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen