C57BL/6JCya-Ptpn20em1flox/Cya
Common Name
Ptpn20-flox
Product ID
S-CKO-04582
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-19256-Ptpn20-B6J-VA
When using this mouse strain in a publication, please cite “Ptpn20-flox Mouse (Catalog S-CKO-04582) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Ptpn20-flox
Strain ID
CKOCMP-19256-Ptpn20-B6J-VA
Gene Name
Product ID
S-CKO-04582
Gene Alias
typ
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 14
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000022508
NCBI RefSeq
NM_008978
Target Region
Exon 4
Size of Effective Region
~1.5 kb
Overview of Gene Research
Ptpn20, encoding protein tyrosine phosphatase non-receptor type 20, is a non-receptor tyrosine phosphatase. It is involved in various biological processes, with its protein-tyrosine phosphatase signaling potentially regulating cell movements during early vertebrate development [4]. Also, it may be associated with protein dephosphorylation as part of the PTPN family [5].
In triple-negative breast cancer (TNBC), Ptpn20 levels are elevated, and it promotes metastasis by activating NF-κB signaling through dephosphorylating p65 at Ser468, thus serving as a potential prognostic marker and therapeutic target [1]. In H-Tx rats, deletion of Ptpn20 leads to enhanced phosphorylation of the NKCC1 cotransporter in the choroid plexus, causing overproduction of cerebrospinal fluid and potentially contributing to hydrocephalus, indicating it could be a therapeutic target for hydrocephalus [2]. In gastric cancer with Helicobacter pylori infection, Ptpn20 is a significant prognostic marker, associated with immune cell infiltration and tumor mutation burden [3].
In summary, Ptpn20 is involved in multiple biological processes and disease conditions. Studies, including gene-knockout-related models in rats and functional studies in cell lines and animal models, have revealed its role in TNBC metastasis, hydrocephalus formation, and gastric cancer prognosis. These findings suggest Ptpn20 could be a valuable target for treatment in these diseases.
References：
1. Zuo, Xiaoxiao, Zhao, Xiaohan, Zhang, Xiaofei, Shi, Dongni, Qian, Xueke. 2024. PTPN20 promotes metastasis through activating NF-κB signaling in triple-negative breast cancer. In Breast cancer research : BCR, 26, 155. doi:10.1186/s13058-024-01910-w. https://pubmed.ncbi.nlm.nih.gov/39506852/
2. Xu, Hanbing, Miyajima, Masakazu, Nakajima, Madoka, Arai, Hajime, Kondo, Akihide. 2022. Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study. In Fluids and barriers of the CNS, 19, 39. doi:10.1186/s12987-022-00341-z. https://pubmed.ncbi.nlm.nih.gov/35658898/
3. Ma, Lianjun, Liu, Yang, Wang, Yizhao, Ye, Shujun, Liu, Yanqing. 2023. Identification of PTPN20 as an innate immunity-related gene in gastric cancer with Helicobacter pylori infection. In Frontiers in immunology, 14, 1212692. doi:10.3389/fimmu.2023.1212692. https://pubmed.ncbi.nlm.nih.gov/37359510/
4. van Eekelen, Mark, Runtuwene, Vincent, Masselink, Wouter, den Hertog, Jeroen. 2012. Pair-wise regulation of convergence and extension cell movements by four phosphatases via RhoA. In PloS one, 7, e35913. doi:10.1371/journal.pone.0035913. https://pubmed.ncbi.nlm.nih.gov/22545146/
5. Wang, Fengxu, Wang, Xuehai, Liu, Lei, Zhao, Xinyuan, Gao, Erli. 2022. Comprehensive analysis of PTPN gene family revealing PTPN7 as a novel biomarker for immuno-hot tumors in breast cancer. In Frontiers in genetics, 13, 981603. doi:10.3389/fgene.2022.981603. https://pubmed.ncbi.nlm.nih.gov/36226189/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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