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C57BL/6JCya-Rab11bem1flox/Cya
Common Name:
Rab11b-flox
Product ID:
S-CKO-04646
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Rab11b-flox
Strain ID
CKOCMP-19326-Rab11b-B6J-VA
Gene Name
Rab11b
Product ID
S-CKO-04646
Gene Alias
A730055L17Rik
Background
C57BL/6JCya
NCBI ID
19326
Modification
Conditional knockout
Chromosome
17
Phenotype
MGI:99425
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Rab11bem1flox/Cya mice (Catalog S-CKO-04646) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000057373
NCBI RefSeq
NM_008997
Target Region
Exon 2
Size of Effective Region
~1.5 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Rab11b, a member of the Rab family of small GTPases, plays crucial roles in membrane trafficking, especially in the recycling of various proteins. It is involved in pathways related to vesicular transport, which is essential for maintaining normal cellular functions. Genetic models, such as KO/CKO mouse models, are valuable tools for studying its functions [1,2,3,4,5].

In an alcohol-associated liver disease (ALD) mouse model, knockdown of Rab11b in macrophages alleviated alcohol-induced liver inflammation, injury, and steatosis. Rab11b activated the NLRP3 inflammasome to induce M1 macrophage polarization and inhibited autophagic flux, suppressing LC3B-mediated NLRP3 degradation [1]. In breast cancer brain metastasis (BCBM) studies, RNA-sequencing and genetic screen in Drosophila melanogaster identified Rab11b as a mediator of metastatic adaptation. It controls integrin β1 recycling, enabling efficient interaction with the brain extracellular matrix and promoting survival. Lipophilic statins, which prevent Rab11b membrane association, can prevent BCBM [2]. In intestinal epithelial progenitor cells, compound ablation of Rab11a and Rab11b in mice led to defective cell cycle entry, mitotic arrest, and apoptosis. Ex vivo, enteroids showed abnormal mitotic spindle formation and cell death. Rab11a and Rab11b share an interactome containing mitotic spindle microtubule regulators [3].

In conclusion, Rab11b is essential for membrane trafficking-related processes. Through model-based research, it has been revealed to be involved in multiple disease-related processes, such as ALD, BCBM, and intestinal epithelial renewal. These findings highlight the significance of Rab11b in understanding disease mechanisms and potentially developing therapeutic strategies.

References:
1. Zhao, Yu-Xin, Sun, Ying-Yin, Li, Liang-Yun, Huang, Cheng, Li, Jun. 2024. Rab11b promotes M1-like macrophage polarization by restraining autophagic degradation of NLRP3 in alcohol-associated liver disease. In Acta pharmacologica Sinica, 46, 134-146. doi:10.1038/s41401-024-01333-5. https://pubmed.ncbi.nlm.nih.gov/38992121/
2. Howe, Erin N, Burnette, Miranda D, Justice, Melanie E, Zartman, Jeremiah J, Zhang, Siyuan. 2020. Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth. In Nature communications, 11, 3017. doi:10.1038/s41467-020-16832-2. https://pubmed.ncbi.nlm.nih.gov/32541798/
3. Joseph, Ivor, Flores, Juan, Farrell, Victoria, Goldenring, James R, Gao, Nan. 2023. RAB11A and RAB11B control mitotic spindle function in intestinal epithelial progenitor cells. In EMBO reports, 24, e56240. doi:10.15252/embr.202256240. https://pubmed.ncbi.nlm.nih.gov/37424454/
4. Schlierf, B, Fey, G H, Hauber, J, Hocke, G M, Rosorius, O. . Rab11b is essential for recycling of transferrin to the plasma membrane. In Experimental cell research, 259, 257-65. doi:. https://pubmed.ncbi.nlm.nih.gov/10942597/
5. Butterworth, Michael B, Edinger, Robert S, Silvis, Mark R, Frizzell, Raymond A, Johnson, John P. 2011. Rab11b regulates the trafficking and recycling of the epithelial sodium channel (ENaC). In American journal of physiology. Renal physiology, 302, F581-90. doi:10.1152/ajprenal.00304.2011. https://pubmed.ncbi.nlm.nih.gov/22129970/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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