C57BL/6JCya-Relnem1flox/Cya
Common Name
Reln-flox
Product ID
S-CKO-04769
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-19699-Reln-B6J-VA
Status
When using this mouse strain in a publication, please cite “Reln-flox Mouse (Catalog S-CKO-04769) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Reln-flox
Strain ID
CKOCMP-19699-Reln-B6J-VA
Gene Name
Product ID
S-CKO-04769
Gene Alias
rl, reeler
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 5
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000161356
NCBI RefSeq
NM_011261
Target Region
Exon 3
Size of Effective Region
~1.2 kb
Overview of Gene Research
Reln, encoding the large extracellular protein Reelin, plays several critical roles in brain development and function. It is involved in regulating neuronal migration and positioning in the developing brain, and sustains functionality in the adult brain. Reelin activates neuronal signal transduction pathways related to synaptic plasticity, dendritic morphology, and cognitive function in the adult brain [1,2].
In humans, biallelic RELN variants are associated with a recessive lissencephaly variant with cerebellar hypoplasia, similar to the homozygous mouse mutant. Monoallelic RELN variants are associated with frontotemporal or temporal-predominant lissencephaly variant, epilepsy, autism, and probably schizophrenia, with incomplete penetrance and variable expressivity. Heterozygous missense variants can cause a severe reduction in overall RELN secretion, suggesting a dominant-negative effect [1]. Mice with exonic RELN deletion showed impaired visual discrimination learning and reversal learning in touchscreen operant tasks, indicating its role in cognitive function [2].
In conclusion, Reln is essential for brain development and function, especially in processes related to neuronal migration, synaptic plasticity, and cognitive function. Studies on RELN-related neurodevelopmental disorders and cognitive impairments in mouse models have deepened our understanding of the gene's role in these processes, potentially providing insights for the treatment of related diseases [1,2].
References：
1. Di Donato, Nataliya, Guerrini, Renzo, Billington, Charles J, Leventer, Richard J, Dobyns, William B. . Monoallelic and biallelic mutations in RELN underlie a graded series of neurodevelopmental disorders. In Brain : a journal of neurology, 145, 3274-3287. doi:10.1093/brain/awac164. https://pubmed.ncbi.nlm.nih.gov/35769015/
2. Liao, Jingzhu, Dong, Geyao, Wulaer, Bolati, Nagai, Taku, Yamada, Kiyofumi. 2021. Mice with exonic RELN deletion identified from a patient with schizophrenia have impaired visual discrimination learning and reversal learning in touchscreen operant tasks. In Behavioural brain research, 416, 113569. doi:10.1016/j.bbr.2021.113569. https://pubmed.ncbi.nlm.nih.gov/34499931/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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