C57BL/6JCya-Roraem1flox/Cya
Common Name:
Rora-flox
Product ID:
S-CKO-04824
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Rora-flox
Strain ID
CKOCMP-19883-Rora-B6J-VA
Gene Name
Product ID
S-CKO-04824
Gene Alias
9530021D13Rik; Nr1f1; ROR1; ROR2; ROR3; nmf267; sg; staggerer; tmgc26
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
9
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Roraem1flox/Cya mice (Catalog S-CKO-04824) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000034766
NCBI RefSeq
NM_013646
Target Region
Exon 4
Size of Effective Region
~1.3 kb
Detailed Document
Overview of Gene Research
Rora, also known as retinoic acid receptor-related orphan receptor-α, is a transcription factor involved in multiple biological processes. It plays a role in regulating circadian rhythms, inflammation, metabolism, and cellular development. Rora is associated with pathways such as those related to cell differentiation, immune regulation, and anti-oncogenesis [1-10].
In a CD4-conditional Rora-knockout mouse model, Rora was found to be important for controlling lung inflammation induced by Nippostrongylus brasiliensis infection in CD4+ T cells, suggesting it is a negative regulator of the immune system [1]. In neuron-specific RORA null mice, prenatal RORA deficiency mimicked maternal diabetes-mediated autism-like behavior, indicating RORA's role in autism-like offspring development [2]. In Roraloxp/loxp Mx-1-Cre mice where Rora was deleted in hematopoietic cells post Pipc induction, there was an accumulation of B cells, showing Rora's role in B cell development [3].
In conclusion, Rora is crucial in various biological processes. Through gene knockout mouse models, its role in immune regulation, autism-like behavior, and B cell development has been revealed. These findings contribute to understanding the mechanisms underlying related diseases and potentially provide new therapeutic targets.
References:
1. Haim-Vilmovsky, Liora, Henriksson, Johan, Walker, Jennifer A, McKenzie, Andrew N J, Teichmann, Sarah A. 2021. Mapping Rora expression in resting and activated CD4+ T cells. In PloS one, 16, e0251233. doi:10.1371/journal.pone.0251233. https://pubmed.ncbi.nlm.nih.gov/34003838/
2. Yu, Hong, Niu, Yanbin, Jia, Guohua, Guo, Xiaoling, Yao, Paul. 2022. Maternal diabetes-mediated RORA suppression in mice contributes to autism-like offspring through inhibition of aromatase. In Communications biology, 5, 51. doi:10.1038/s42003-022-03005-8. https://pubmed.ncbi.nlm.nih.gov/35027651/
3. Li, Ning, Wang, Nan, He, Wei, Zhang, Haojian, Hu, Yiguo. 2022. The suppressive functions of Rora in B lineage cell proliferation and BCR/ABL1-induced B-ALL pathogenesis. In International journal of biological sciences, 18, 2277-2291. doi:10.7150/ijbs.68939. https://pubmed.ncbi.nlm.nih.gov/35414788/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen