C57BL/6JCya-Rxrbem1flox/Cya
Common Name
Rxrb-flox
Product ID
S-CKO-04886
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-20182-Rxrb-B6J-VA
Status
When using this mouse strain in a publication, please cite “Rxrb-flox Mouse (Catalog S-CKO-04886) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Rxrb-flox
Strain ID
CKOCMP-20182-Rxrb-B6J-VA
Gene Name
Product ID
S-CKO-04886
Gene Alias
Rub, Nr2b2, RCoR-1, H-2RIIBP
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 17
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000044858
NCBI RefSeq
NM_001205214
Target Region
Exon 3~4
Size of Effective Region
~1.2 kb
Overview of Gene Research
Rxrb, encoding Retinoid X receptor beta, is a member of the retinoid X receptor family of nuclear receptors involved in mediating retinoic acid effects [5]. It can form heterodimers with peroxisome proliferator-activated receptors (PPARs) and is crucial for cholesterol homeostasis, spermiation, and chromatin remodeling [3,4].
In Sertoli cells, somatic targeted inactivation of Rxrb (Rxrb(Ser-/-) mutants) leads to failure of spermatid release and cholesterol ester accumulation, causing testis degeneration, indicating its key role in male reproduction [4]. In systemic sclerosis, exome sequencing identified rs17847931 in RXRB as a susceptibility variant, suggesting its involvement in antifibrotic activity in skin and chromatin remodeling [1]. In cancer, the RAB39A-RXRB axis was found to be important for cancer development and stemness, with RXRB being a major effector of RAB39A [2].
In conclusion, Rxrb plays essential roles in male reproduction, is associated with disease susceptibilities like systemic sclerosis, and is involved in cancer-related processes. Mouse models, such as the Rxrb(Ser-/-) mutants, have been instrumental in revealing its functions in male reproductive pathophysiology, while human-based genetic studies have shed light on its role in autoimmune and cancer-related conditions.
References：
1. Oka, Akira, Asano, Yoshihide, Hasegawa, Minoru, Sato, Shinichi, Ihn, Hironobu. 2017. RXRB Is an MHC-Encoded Susceptibility Gene Associated with Anti-Topoisomerase I Antibody-Positive Systemic Sclerosis. In The Journal of investigative dermatology, 137, 1878-1886. doi:10.1016/j.jid.2017.04.028. https://pubmed.ncbi.nlm.nih.gov/28506627/
2. Chano, Tokuhiro, Kita, Hiroko, Avnet, Sofia, Lemma, Silvia, Baldini, Nicola. 2018. Prominent role of RAB39A-RXRB axis in cancer development and stemness. In Oncotarget, 9, 9852-9866. doi:10.18632/oncotarget.23955. https://pubmed.ncbi.nlm.nih.gov/29515775/
3. Wieczorek, Stefan, Knaup, Silvia, Gross, Wolfgang L, Epplen, Jörg T. 2009. Genetic variability of RXRB, PPARA, and PPARG in Wegener's granulomatosis. In PPAR research, 2009, 786781. doi:10.1155/2009/786781. https://pubmed.ncbi.nlm.nih.gov/19223982/
4. Vernet, Nadège, Dennefeld, Christine, Klopfenstein, Muriel, Ghyselinck, Norbert B, Mark, Manuel. 2008. Retinoid X receptor beta (RXRB) expression in Sertoli cells controls cholesterol homeostasis and spermiation. In Reproduction (Cambridge, England), 136, 619-26. doi:10.1530/REP-08-0235. https://pubmed.ncbi.nlm.nih.gov/18713813/
5. Nagata, T, Kanno, Y, Ozato, K, Taketo, M. . The mouse Rxrb gene encoding RXR beta: genomic organization and two mRNA isoforms generated by alternative splicing of transcripts initiated from CpG island promoters. In Gene, 142, 183-9. doi:. https://pubmed.ncbi.nlm.nih.gov/8194750/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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