C57BL/6JCya-Clec11aem1flox/Cya
Common Name
Clec11a-flox
Product ID
S-CKO-04927
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-20256-Clec11a-B6J-VA
When using this mouse strain in a publication, please cite “Clec11a-flox Mouse (Catalog S-CKO-04927) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Clec11a-flox
Strain ID
CKOCMP-20256-Clec11a-B6J-VA
Gene Name
Product ID
S-CKO-04927
Gene Alias
Scgf, Clecsf3
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 7
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000004587
NCBI RefSeq
NM_009131
Target Region
Exon 3~4
Size of Effective Region
~3.5 kb
Overview of Gene Research
Clec11a, also known as stem cell growth factor (SCGF), C-type lectin superfamily member 3 (CLECSF3), or osteolectin, is a sulfated glycoprotein. It significantly promotes the osteogenic differentiation of bone marrow mesenchymal stem cells and osteoblasts, stimulates chondrocyte proliferation, and is involved in the stress/adaptive response of bone to exercise via mechanical stimulation of the cation channel Pieoz1. It also plays a role in regulating hematopoietic differentiation and homeostasis [2,3].
In osteoporosis mouse models, human umbilical cord mesenchymal stromal cell-derived extracellular vesicles (hucMSC-EVs) prevent bone loss and maintain bone strength by enhancing bone formation, reducing marrow fat accumulation, and decreasing bone resorption. This is achieved through CLEC11A-mediated regulation of bone metabolism. Specifically, CLEC11A in hucMSC-EVs enhances the shift from adipogenic to osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSCs) and inhibits osteoclast formation [1].
In summary, Clec11a is crucial for bone health, playing key roles in bone construction, remodeling, and metabolism. Its study, especially through models like those involving hucMSC-EVs in osteoporosis, provides insights into potential therapeutic strategies for bone diseases [1,2].
References：
1. Hu, Yin, Zhang, Yan, Ni, Chu-Yu, Luo, Juan, Xie, Hui. 2020. Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism. In Theranostics, 10, 2293-2308. doi:10.7150/thno.39238. https://pubmed.ncbi.nlm.nih.gov/32089743/
2. Xu, Ke, Huang, Rui-Qi, Wen, Ruiming, Cheng, Yang, Chang, Bo. 2024. The role of Clec11a in bone construction and remodeling. In Frontiers in endocrinology, 15, 1429567. doi:10.3389/fendo.2024.1429567. https://pubmed.ncbi.nlm.nih.gov/39188913/
3. Wang, Miao, Guo, Jianmin, Zhang, Lingli, Xu, Jiake, Zou, Jun. 2020. Molecular structure, expression, and functional role of Clec11a in skeletal biology and cancers. In Journal of cellular physiology, 235, 6357-6365. doi:10.1002/jcp.29600. https://pubmed.ncbi.nlm.nih.gov/32003015/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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