C57BL/6JCya-Slc16a7em1flox/Cya
Common Name:
Slc16a7-flox
Product ID:
S-CKO-05086
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Slc16a7-flox
Strain ID
CKOCMP-20503-Slc16a7-B6J-VA
Gene Name
Product ID
S-CKO-05086
Gene Alias
4921534N07Rik; 9030411M13Rik; D630004K10Rik; Mct2
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
10
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Slc16a7em1flox/Cya mice (Catalog S-CKO-05086) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000211781
NCBI RefSeq
NM_001358496
Target Region
Exon 5
Size of Effective Region
~1.4 kb
Detailed Document
Overview of Gene Research
Slc16a7, encoding monocarboxylate transporter 2 (MCT2), catalyzes the proton-linked transport of monocarboxylates like l-lactate, pyruvate and ketone bodies across the plasma membrane, and is involved in energy metabolism pathways in various tissues [2]. It plays a role in multiple biological processes and is associated with different diseases.
In chicken, Slc16a7 promotes triglyceride deposition by de novo lipogenesis in muscle tissue, highlighting a potential intramuscular fat deposition pathway [1]. In prostate cancer, selective demethylation of an internal Slc16a7 promoter leads to protein over-expression, and its knockdown attenuates PCa cell growth, suggesting a link to oncogenic pathways [4]. In head and neck squamous cell carcinoma, patients with low Slc16a7 expression have a higher risk of occult lymph node metastases [3].
In conclusion, Slc16a7 is crucial for monocarboxylate transport and energy metabolism. Its dysregulation is associated with diseases such as cancer and abnormal lipid deposition in muscle. Research on Slc16a7 provides insights into the underlying mechanisms of these conditions, which may contribute to the development of new therapeutic strategies.
References：
1. Wang, Yongli, Liu, Lu, Liu, Xiaojing, Cui, Huanxian, Wen, Jie. 2022. SLC16A7 Promotes Triglyceride Deposition by De Novo Lipogenesis in Chicken Muscle Tissue. In Biology, 11, . doi:10.3390/biology11111547. https://pubmed.ncbi.nlm.nih.gov/36358250/
2. Halestrap, Andrew P. . The SLC16 gene family - structure, role and regulation in health and disease. In Molecular aspects of medicine, 34, 337-49. doi:10.1016/j.mam.2012.05.003. https://pubmed.ncbi.nlm.nih.gov/23506875/
3. Camacho, Mercedes, Vázquez-López, Cristina, Valero, Cristina, Avilés-Jurado, Francesc Xavier, León, Xavier. 2024. Transcriptional expression of SLC16A7 as a biomarker of occult lymph node metastases in patients with head and neck squamous cell carcinoma. In European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 281, 6637-6644. doi:10.1007/s00405-024-08882-9. https://pubmed.ncbi.nlm.nih.gov/39215860/
4. Pertega-Gomes, Nelma, Vizcaino, Jose R, Felisbino, Sergio, Neal, David E, Massie, Charles E. . Epigenetic and oncogenic regulation of SLC16A7 (MCT2) results in protein over-expression, impacting on signalling and cellular phenotypes in prostate cancer. In Oncotarget, 6, 21675-84. doi:. https://pubmed.ncbi.nlm.nih.gov/26035357/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen