C57BL/6JCya-Slc22a1em1flox/Cya
Common Name:
Slc22a1-flox
Product ID:
S-CKO-05096
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Slc22a1-flox
Strain ID
CKOCMP-20517-Slc22a1-B6J-VA
Gene Name
Product ID
S-CKO-05096
Gene Alias
Lx1; Oct1; Orct; Orct1
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
17
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Slc22a1em1flox/Cya mice (Catalog S-CKO-05096) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000024596
NCBI RefSeq
NM_009202
Target Region
Exon 4
Size of Effective Region
~1.9 kb
Detailed Document
Overview of Gene Research
Slc22a1, also known as the gene encoding the broad selectivity transporter hOCT1, is expressed in most epithelial barriers and different drug target cells [2]. It contributes to drug pharmacokinetics and pharmacodynamics, mediating the translocation of various drugs, such as metformin, anticancer, antiviral, anti-inflammatory agents [2].
In chronic myeloid leukemia (CML), carriers of SLC22A1 rs628031A allele or rs683369G allele are associated with a lower major molecular response (MMR) rate to imatinib treatment [1]. In Mexican women, genetic variants in SLC22A1 are related to serum lipid levels, with certain genotypes and haplotypes associated with changes in cholesterol and lipoprotein levels [3]. In children with acute lymphoblastic leukemia in the Amazon region, the SLC22A1 gene variant is associated with a higher risk of severe infectious toxicity during treatment [4].
In conclusion, Slc22a1 plays a crucial role in drug disposition and therapeutic responses. Its genetic variants are associated with different disease-related outcomes, including drug response in CML, lipid metabolism in Mexican women, and treatment-related toxicity in childhood leukemia. Understanding Slc22a1 through genetic models helps uncover its role in these biological processes and disease conditions.
References：
1. Cargnin, Sarah, Ravegnini, Gloria, Soverini, Simona, Angelini, Sabrina, Terrazzino, Salvatore. 2018. Impact of SLC22A1 and CYP3A5 genotypes on imatinib response in chronic myeloid leukemia: A systematic review and meta-analysis. In Pharmacological research, 131, 244-254. doi:10.1016/j.phrs.2018.02.005. https://pubmed.ncbi.nlm.nih.gov/29427770/
2. Arimany-Nardi, C, Koepsell, H, Pastor-Anglada, M. 2015. Role of SLC22A1 polymorphic variants in drug disposition, therapeutic responses, and drug-drug interactions. In The pharmacogenomics journal, 15, 473-87. doi:10.1038/tpj.2015.78. https://pubmed.ncbi.nlm.nih.gov/26526073/
3. Cahua-Pablo, José Ángel, Gómez-Zamudio, Jaime Héctor, Reséndiz-Abarca, Carlos Alberto, Zubillaga-Guerrero, Ma Isabel, Flores-Alfaro, Eugenia. 2021. Genetic variants in SLC22A1 are related to serum lipid levels in Mexican women. In Lipids, 57, 105-114. doi:10.1002/lipd.12334. https://pubmed.ncbi.nlm.nih.gov/34927264/
4. Fernandes, Sweny de S M, Leitão, Luciana P C, Cohen-Paes, Amanda de N, Santos, Sidney E B Dos, Santos, Ney P C Dos. 2022. The Role of SLC22A1 and Genomic Ancestry on Toxicity during Treatment in Children with Acute Lymphoblastic Leukemia of the Amazon Region. In Genes, 13, . doi:10.3390/genes13040610. https://pubmed.ncbi.nlm.nih.gov/35456416/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen