C57BL/6JCya-Sox7em1flox/Cya
Common Name
Sox7-flox
Product ID
S-CKO-05189
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-20680-Sox7-B6J-VA
When using this mouse strain in a publication, please cite “Sox7-flox Mouse (Catalog S-CKO-05189) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Sox7-flox
Strain ID
CKOCMP-20680-Sox7-B6J-VA
Gene Name
Product ID
S-CKO-05189
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
Chr 14
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000079652
NCBI RefSeq
NM_011446
Target Region
Exon 2
Size of Effective Region
~3.9 kb
Overview of Gene Research
Sox7, a member of the SOX (SRY-related HMG-box) family of transcription factors, plays crucial roles in multiple biological processes. It is involved in hematopoiesis, vasculogenesis, and cardiogenesis during embryonic development [2]. In the cardiovascular system, it is associated with pathways such as VEGF/Flk1 signaling, Wnt signaling, and the Notch pathway [3].
In mice, endothelial-specific loss of Sox7 function leads to cardiac ventricular defects similar to non-compaction cardiomyopathy, with abnormal coronary artery formation. This phenotype is due to disrupted transcriptional regulation of the Notch pathway and connexins 37 and 40, as well as depletion of a subset of Sox9/Gpc3-positive endocardial progenitor cells and an increase in erythro-myeloid cell lineages. Some Sox7-null endothelial cells transdifferentiate into hematopoietic lineages [1]. In addition, Sox7-overexpression in BCa cell lines inhibits the proliferative, migratory, and invasive capabilities of BCa, via the DNMT3B/CYGB axis [4].
In conclusion, Sox7 is essential for maintaining cardiac endothelial cell identity, which is crucial for ventricular compaction and coronary artery development. It also plays a tumor-suppressive role in various cancers like bladder cancer. The study of Sox7 using gene-knockout mouse models has provided valuable insights into its functions in heart development-related diseases and cancer [1,2,4].
References：
1. Chiang, Ivy Kn, Humphrey, David, Mills, Richard J, Del Monte-Nieto, Gonzalo, Francois, Mathias. 2023. Sox7-positive endothelial progenitors establish coronary arteries and govern ventricular compaction. In EMBO reports, 24, e55043. doi:10.15252/embr.202255043. https://pubmed.ncbi.nlm.nih.gov/37551717/
2. Stovall, Daniel B, Cao, Paul, Sui, Guangchao. 2013. SOX7: from a developmental regulator to an emerging tumor suppressor. In Histology and histopathology, 29, 439-45. doi:10.14670/HH-29.10.439. https://pubmed.ncbi.nlm.nih.gov/24288056/
3. Wat, Jeanette J, Wat, Margaret J. . Sox7 in vascular development: review, insights and potential mechanisms. In The International journal of developmental biology, 58, 1-8. doi:10.1387/ijdb.130323mw. https://pubmed.ncbi.nlm.nih.gov/24860989/
4. Zhang, Jingcheng, Zhang, Wentao, Liu, Ji, Yao, Xudong, Yan, Yang. 2024. SOX7 inhibits the malignant progression of bladder cancer via the DNMT3B/CYGB axis. In Molecular biomedicine, 5, 36. doi:10.1186/s43556-024-00198-8. https://pubmed.ncbi.nlm.nih.gov/39227479/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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