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C57BL/6NCya-Srebf1em1flox/Cya
Common Name:
Srebf1-flox
Product ID:
S-CKO-05277
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Srebf1-flox
Strain ID
CKOCMP-20787-Srebf1-B6N-VA
Gene Name
Srebf1
Product ID
S-CKO-05277
Gene Alias
ADD1; SREBP1; bHLHd1
Background
C57BL/6NCya
NCBI ID
20787
Modification
Conditional knockout
Chromosome
11
Phenotype
MGI:107606
Document
Click here to download >>
Application
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More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Srebf1em1flox/Cya mice (Catalog S-CKO-05277) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000020846
NCBI RefSeq
NM_011480
Target Region
Exon 2~5
Size of Effective Region
~2.0 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Srebf1, also known as sterol regulatory element binding transcription factor 1 (SREBP-1), is a key lipogenic transcription factor. It plays a crucial role in lipid metabolism, participating in pathways related to lipid synthesis, uptake, storage, and liberation, thus maintaining lipid homeostasis. It is also involved in various biological processes such as midbrain dopaminergic neurogenesis [6].

In cancer research, Srebf1 has been found to be essential in multiple ways. In tumor cells, it concurrently regulates lipid synthesis and lipophagy to maintain lipid homeostasis for rapid tumor growth, suggesting it as a potential target for cancer treatment [1]. In pancreatic cancer, BHLHE40 upregulates Srebf1 to inhibit ferroptosis [2]. In renal cell carcinoma, TRIM21 regulates Srebf1 protein stability to attenuate lipogenesis and malignancy, and the two are correlated as a biomarker for prognosis [3]. In squamous cell carcinomas, Srebf1 is a central mediator linking TP63 with fatty-acid metabolism and is essential for SCC viability and migration [4]. In esophageal squamous cell carcinoma, PRP19 enhances fatty acid synthesis through Srebf1 to promote cancer progression [5]. Additionally, a gain-of-function variant in Srebf1 causes generalized skin hyperpigmentation with congenital cataracts, revealing its involvement in melanogenesis and lens development [7].

In conclusion, Srebf1 is a vital regulator in lipid metabolism and is implicated in multiple disease areas, especially cancer. Studies using various models, although not specifically KO/CKO mouse models in the provided references, have revealed its significant roles in maintaining lipid homeostasis and promoting tumor growth, providing potential therapeutic targets for cancer treatment and new insights into understanding melanogenesis and lens-related disorders.

References:
1. Geng, Feng, Guo, Deliang. 2023. SREBF1/SREBP-1 concurrently regulates lipid synthesis and lipophagy to maintain lipid homeostasis and tumor growth. In Autophagy, 20, 1183-1185. doi:10.1080/15548627.2023.2275501. https://pubmed.ncbi.nlm.nih.gov/37927089/
2. Cao, Yizhi, Wang, Xuelong, Liu, Yang, Jiang, Lingxi, Shen, Baiyong. 2023. BHLHE40 Inhibits Ferroptosis in Pancreatic Cancer Cells via Upregulating SREBF1. In Advanced science (Weinheim, Baden-Wurttemberg, Germany), 11, e2306298. doi:10.1002/advs.202306298. https://pubmed.ncbi.nlm.nih.gov/38064101/
3. Chen, Xintian, Yong, Hongmei, Chen, Miaolei, Li, Zhongwei, Bai, Jin. 2023. TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability. In Journal of experimental & clinical cancer research : CR, 42, 34. doi:10.1186/s13046-022-02583-z. https://pubmed.ncbi.nlm.nih.gov/36694250/
4. Li, Li-Yan, Yang, Qian, Jiang, Yan-Yi, Koeffler, H Phillip, Lin, De-Chen. 2021. Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer. In Nature communications, 12, 4362. doi:10.1038/s41467-021-24656-x. https://pubmed.ncbi.nlm.nih.gov/34272396/
5. Zhang, Guang-Cong, Yu, Xiang-Nan, Guo, Hong-Ying, Shen, Xi-Zhong, Yin, Jie. . PRP19 Enhances Esophageal Squamous Cell Carcinoma Progression by Reprogramming SREBF1-Dependent Fatty Acid Metabolism. In Cancer research, 83, 521-537. doi:10.1158/0008-5472.CAN-22-2156. https://pubmed.ncbi.nlm.nih.gov/36723974/
6. Toledo, Enrique M, Yang, Shanzheng, Gyllborg, Daniel, Linnarsson, Sten, Arenas, Ernest. . Srebf1 Controls Midbrain Dopaminergic Neurogenesis. In Cell reports, 31, 107601. doi:10.1016/j.celrep.2020.107601. https://pubmed.ncbi.nlm.nih.gov/32375051/
7. Wang, Huijun, Wu, Yuan, Bassetti, Jennifer A, Xu, Zigang, Lin, Zhimiao. . A gain-of-function variant in SREBF1 causes generalized skin hyperpigmentation with congenital cataracts. In The British journal of dermatology, 191, 805-815. doi:10.1093/bjd/ljae291. https://pubmed.ncbi.nlm.nih.gov/39005171/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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