C57BL/6JCya-Rbmx2em1flox/Cya
Common Name:
Rbmx2-flox
Product ID:
S-CKO-05404
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Rbmx2-flox
Strain ID
CKOCMP-209003-Rbmx2-B6J-VA
Gene Name
Product ID
S-CKO-05404
Gene Alias
2700089A17Rik; 2810411A03Rik; CGI-79
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
X
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Rbmx2em1flox/Cya mice (Catalog S-CKO-05404) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000033433
NCBI RefSeq
NM_173376
Target Region
Exon 3
Size of Effective Region
~1.2 kb
Detailed Document
Overview of Gene Research
Rbmx2, short for RNA binding motif protein, X-linked 2, is involved in various biological processes. It participates in transcription regulation of cells [1]. It may also play a role in processes related to apoptosis, as suggested by its function in promoting epithelial cell apoptosis by down-regulating APAF-1's retention intron after Mycobacterium bovis infection [2]. Additionally, it has been linked to bipolar disorder, with an Alu element deletion in its gene potentially contributing to the disease development [3].
In the context of Theileria annulata infection, the protein TA05575 of this parasite was found to interact with RBMX2-like protein, which may contribute to the transformation of bovine leukocytes, as the distribution of TA05575 in the nucleus might be related to cell transformation [1]. In Mycobacterium bovis infection, knocking out RBMX2 led to significant enrichment in RNA splicing associated with apoptosis in embryo bovine lung cells compared to wild-type cells, indicating its role in promoting apoptosis during infection [2].
In conclusion, Rbmx2 is involved in transcription regulation and apoptosis-related processes. Findings from the study of its interactions in Theileria annulata-infected cells and its role in Mycobacterium bovis-induced apoptosis provide insights into pathogen-host interactions and disease-related cellular processes. The association with bipolar disorder also points to its potential significance in neurological disease mechanisms.
References:
1. Li, Zhi, Liu, Junlong, Zhao, Shuaiyang, Luo, Jianxun, Yin, Hong. 2021. Theileria annulata Subtelomere-Encoded Variable Secreted Protein-TA05575 Binds to Bovine RBMX2. In Frontiers in cellular and infection microbiology, 11, 644983. doi:10.3389/fcimb.2021.644983. https://pubmed.ncbi.nlm.nih.gov/33718289/
2. Wang, Chao, Jiang, Yanzhu, Yang, Zhiming, Guo, Aizhen, Chen, Yingyu. 2024. Host factor RBMX2 promotes epithelial cell apoptosis by downregulating APAF-1's Retention Intron after Mycobacterium bovis infection. In Frontiers in immunology, 15, 1431207. doi:10.3389/fimmu.2024.1431207. https://pubmed.ncbi.nlm.nih.gov/39308873/
3. Laine, Pia, Rowell, William J, Paulin, Lars, Auvinen, Petri, Ekholm, Jenny M. 2021. Alu element in the RNA binding motif protein, X-linked 2 (RBMX2) gene found to be linked to bipolar disorder. In PloS one, 16, e0261170. doi:10.1371/journal.pone.0261170. https://pubmed.ncbi.nlm.nih.gov/34914762/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen