C57BL/6JCya-Zc3hav1lem1flox/Cya
Common Name:
Zc3hav1l-flox
Product ID:
S-CKO-05411
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Zc3hav1l-flox
Strain ID
CKOCMP-209032-Zc3hav1l-B6J-VA
Gene Name
Product ID
S-CKO-05411
Gene Alias
B130055L09Rik; E430016P22Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
6
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Zc3hav1lem1flox/Cya mice (Catalog S-CKO-05411) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000058524
NCBI RefSeq
NM_172467
Target Region
Exon 3
Size of Effective Region
~1.2 kb
Detailed Document
Overview of Gene Research
Zc3hav1l, whose functions are still being elucidated, has been associated with various biological implications. In pigs, it may be involved in the regulation of porcine leanness as a nonsense mutation in Zc3hav1l on SSC18 has a direct effect on lean meat percentage [2]. In humans, from RNA-seq data of normal human mammary epithelial cells, an interchromosomal RNA fusion between ZC3HAV1L and CHMP1A was computationally detected and experimentally confirmed in multiple human cells and tissues, with three variants of the chimeric RNA detected, suggesting complex splicing likely via trans-splicing [1]. Also, in colon cancer, Zc3hav1l is part of a risk score system consisting of eight immune-related genes constructed to predict the prognosis of colon cancer patients [3].
Although no gene knockout (KO) or conditional knockout (CKO) mouse models are mentioned in the provided references, these findings indicate Zc3hav1l could potentially play a role in processes related to porcine leanness, human cell splicing, and colon cancer prognosis.
In summary, Zc3hav1l seems to be involved in multiple biological processes such as porcine leanness regulation, human cell RNA splicing, and in predicting colon cancer prognosis. While KO/CKO mouse models were not detailed in the given references, future studies using such models could further clarify its role in these and potentially other disease-related or biological processes.
References:
1. Fang, Wenwen, Wei, Yong, Kang, Yibin, Landweber, Laura F. 2012. Detection of a common chimeric transcript between human chromosomes 7 and 16. In Biology direct, 7, 49. doi:10.1186/1745-6150-7-49. https://pubmed.ncbi.nlm.nih.gov/23273016/
2. Ibragimov, Emil, Pedersen, Anni Øyan, Sloth, Niels Morten, Fredholm, Merete, Karlskov-Mortensen, Peter. 2024. Identification of a novel QTL for lean meat percentage using imputed genotypes. In Animal genetics, 55, 658-663. doi:10.1111/age.13442. https://pubmed.ncbi.nlm.nih.gov/38752377/
3. Zhang, Jun-Rong, Hou, Ping, Wang, Xiao-Jie, Huang, Zheng-Yuan, Chen, Xian-Qiang. 2021. TNFRSF11B Suppresses Memory CD4+ T Cell Infiltration in the Colon Cancer Microenvironment: A Multiomics Integrative Analysis. In Frontiers in immunology, 12, 742358. doi:10.3389/fimmu.2021.742358. https://pubmed.ncbi.nlm.nih.gov/34938284/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen